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Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed:32929201)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9EP73"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28813410"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28813417"}],"value":"The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813410, PubMed:28813417). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11015443"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18287011"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26602187"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28813410"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28813417"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32929201"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36727298"}],"value":"Interacts with PDCD1 (PubMed:11015443, PubMed:18287011, PubMed:26602187). Interacts (via transmembrane domain) with CMTM4 and CMTM6 (PubMed:28813410, PubMed:28813417). Interacts with (phosphorylated) STAT3; promoting nuclear translocation (PubMed:32929201). 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