{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P61604","secondaryAccessions":["O95421","Q04984","Q53X54","Q9UDH0"],"uniProtkbId":"CH10_HUMAN","entryAudit":{"firstPublicDate":"2004-05-24","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2007-01-23","entryVersion":182,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"10 kDa heat shock protein, mitochondrial"},"shortNames":[{"value":"Hsp10"}]},"alternativeNames":[{"fullName":{"value":"10 kDa chaperonin"}},{"fullName":{"value":"Chaperonin 10"},"shortNames":[{"value":"CPN10"}]},{"fullName":{"value":"Early-pregnancy factor"},"shortNames":[{"value":"EPF"}]},{"fullName":{"value":"Heat shock protein family E member 1"}}]},"genes":[{"geneName":{"value":"HSPE1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11422376"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1346131"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7912672"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25918392"}],"value":"Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131, PubMed:7912672). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25918392"}],"value":"Homoheptamer arranged in a ring structure (PubMed:25918392). 2 heptameric Hsp10 rings interact with a Hsp60 tetradecamer in the structure of a back-to-back double heptameric ring to form the symmetrical football complex (PubMed:25918392)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P61604","intActId":"EBI-711483"},"interactantTwo":{"uniProtKBAccession":"Q96HA8","geneName":"NTAQ1","intActId":"EBI-741158"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61604","intActId":"EBI-711483"},"interactantTwo":{"uniProtKBAccession":"Q8WWX9","geneName":"SELENOM","intActId":"EBI-10277687"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Mitochondrion matrix","id":"SL-0170"}}]},{"texts":[{"value":"By stress"}],"commentType":"INDUCTION"},{"commentType":"MASS SPECTROMETRY","method":"Electrospray","molWeight":10843.5,"molWeightError":0.2,"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7912672"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the GroES chaperonin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"10 kDa heat shock protein, mitochondrial","featureId":"PRO_0000174917"},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"}]},{"type":"Modified residue","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64433"}]},{"type":"Modified residue","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"N6-succinyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64433"}]},{"type":"Modified residue","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64433"}]},{"type":"Modified residue","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"N6-malonyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21908771"}]},{"type":"Modified residue","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64433"}]},{"type":"Modified residue","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"N6-malonyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21908771"}]},{"type":"Modified residue","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64433"}]},{"type":"Modified residue","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"N6-malonyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21908771"}]},{"type":"Modified residue","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64433"}]},{"type":"Modified residue","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64433"}]},{"type":"Modified residue","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64433"}]},{"type":"Modified residue","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64433"}]},{"type":"Modified residue","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64433"}]},{"type":"Modified residue","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64433"}]},{"type":"Modified residue","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64433"}]},{"type":"Modified residue","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64433"}]},{"type":"Modified residue","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Beta strand","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9ES0"}]},{"type":"Beta strand","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8G7N"}]},{"type":"Beta strand","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9ES0"}]},{"type":"Helix","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9ES0"}]},{"type":"Beta strand","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8G7N"}]},{"type":"Turn","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8G7N"}]},{"type":"Beta strand","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9ES0"}]},{"type":"Beta strand","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9ES0"}]},{"type":"Helix","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9ES0"}]},{"type":"Beta strand","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9ES0"}]},{"type":"Beta strand","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9ES0"}]},{"type":"Beta strand","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9ES0"}]},{"type":"Beta strand","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8G7N"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0346","category":"Biological process","name":"Stress response"}],"references":[{"referenceNumber":1,"citation":{"id":"7914093","citationType":"journal article","authors":["Monzini N.","Legname G.","Marcucci F.","Gromo G.","Modena D."],"citationCrossReferences":[{"database":"PubMed","id":"7914093"},{"database":"DOI","id":"10.1016/0167-4781(94)90211-9"}],"title":"Identification and cloning of human chaperonin 10 homologue.","publicationDate":"1994","journal":"Biochim. Biophys. Acta","firstPage":"478","lastPage":"480","volume":"1218"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"7916212","citationType":"journal article","authors":["Chen J.J.","McNealy D.J.","Dalal S.","Androphy E.J."],"citationCrossReferences":[{"database":"PubMed","id":"7916212"},{"database":"DOI","id":"10.1016/0167-4781(94)90268-2"}],"title":"Isolation, sequence analysis and characterization of a cDNA encoding human chaperonin 10.","publicationDate":"1994","journal":"Biochim. Biophys. Acta","firstPage":"189","lastPage":"190","volume":"1219"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":3,"citation":{"id":"12483302","citationType":"journal article","authors":["Hansen J.J.","Bross P.","Westergaard M.","Nielsen M.N.","Eiberg H.","Boerglum A.D.","Mogensen J.","Kristiansen K.","Bolund L.","Gregersen N."],"citationCrossReferences":[{"database":"PubMed","id":"12483302"},{"database":"DOI","id":"10.1007/s00439-002-0837-9"}],"title":"Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.","publicationDate":"2003","journal":"Hum. Genet.","firstPage":"71","lastPage":"77","volume":"112"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"CI-D49PLCHMKUIEL","citationType":"submission","authors":["Ebert L.","Schick M.","Neubert P.","Schatten R.","Henze S.","Korn B."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"MAY-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":6,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"10763410","citationType":"journal article","authors":["Summers K.M.","Fletcher B.H.","Macaranas D.D.","Somodevilla-Torres M.J.","Murphy R.M.","Osborne M.J.","Spurr N.K.","Cassady A.I.","Cavanagh A.C."],"citationCrossReferences":[{"database":"PubMed","id":"10763410"},{"database":"DOI","id":"10.1023/a:1024488422990"}],"title":"Mapping and characterization of the eukaryotic early pregnancy factor/chaperonin 10 gene family.","publicationDate":"1998","journal":"Somat. Cell Mol. Genet.","firstPage":"315","lastPage":"326","volume":"24"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-100"]},{"referenceNumber":10,"citation":{"id":"CI-590AOP3LEV9F","citationType":"submission","authors":["Bienvenut W.V."],"publicationDate":"MAR-2005","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 2-15; 41-54; 57-66 AND 81-92","CLEAVAGE OF INITIATOR METHIONINE","ACETYLATION AT ALA-2","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"B-cell lymphoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"7912672","citationType":"journal article","authors":["Cavanagh A.C.","Morton H."],"citationCrossReferences":[{"database":"PubMed","id":"7912672"},{"database":"DOI","id":"10.1111/j.1432-1033.1994.tb18897.x"}],"title":"The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10.","publicationDate":"1994","journal":"Eur. J. Biochem.","firstPage":"551","lastPage":"560","volume":"222"},"referencePositions":["PROTEIN SEQUENCE OF 8-19; 28-54 AND 70-102","MASS SPECTROMETRY","FUNCTION"],"referenceComments":[{"value":"Platelet","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"1346131","citationType":"journal article","authors":["Viitanen P.V.","Lorimer G.H.","Seetharam R.","Gupta R.S.","Oppenheim J.","Thomas J.O.","Cowan N.J."],"citationCrossReferences":[{"database":"PubMed","id":"1346131"},{"database":"DOI","id":"10.1016/s0021-9258(18)48338-x"}],"title":"Mammalian mitochondrial chaperonin 60 functions as a single toroidal ring.","publicationDate":"1992","journal":"J. Biol. Chem.","firstPage":"695","lastPage":"698","volume":"267"},"referencePositions":["FUNCTION"]},{"referenceNumber":13,"citation":{"id":"11422376","citationType":"journal article","authors":["Levy-Rimler G.","Viitanen P.","Weiss C.","Sharkia R.","Greenberg A.","Niv A.","Lustig A.","Delarea Y.","Azem A."],"citationCrossReferences":[{"database":"PubMed","id":"11422376"},{"database":"DOI","id":"10.1046/j.1432-1327.2001.02243.x"}],"title":"The effect of nucleotides and mitochondrial chaperonin 10 on the structure and chaperone activity of mitochondrial chaperonin 60.","publicationDate":"2001","journal":"Eur. J. Biochem.","firstPage":"3465","lastPage":"3472","volume":"268"},"referencePositions":["FUNCTION"]},{"referenceNumber":14,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-56; LYS-86 AND LYS-99","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":15,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-79","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":17,"citation":{"id":"21908771","citationType":"journal article","authors":["Peng C.","Lu Z.","Xie Z.","Cheng Z.","Chen Y.","Tan M.","Luo H.","Zhang Y.","He W.","Yang K.","Zwaans B.M.","Tishkoff D.","Ho L.","Lombard D.","He T.C.","Dai J.","Verdin E.","Ye Y.","Zhao Y."],"citationCrossReferences":[{"database":"PubMed","id":"21908771"},{"database":"DOI","id":"10.1074/mcp.m111.012658"}],"title":"The first identification of lysine malonylation substrates and its regulatory enzyme.","publicationDate":"2011","journal":"Mol. Cell. Proteomics","firstPage":"M111.012658.01","lastPage":"M111.012658.12","volume":"10"},"referencePositions":["MALONYLATION AT LYS-40; LYS-54 AND LYS-56"]},{"referenceNumber":18,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":19,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":20,"citation":{"id":"25918392","citationType":"journal article","authors":["Nisemblat S.","Yaniv O.","Parnas A.","Frolow F.","Azem A."],"citationCrossReferences":[{"database":"PubMed","id":"25918392"},{"database":"DOI","id":"10.1073/pnas.1411718112"}],"title":"Crystal structure of the human mitochondrial chaperonin symmetrical football complex.","publicationDate":"2015","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"6044","lastPage":"6049","volume":"112"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.15 ANGSTROMS)","SUBUNIT","FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X75821","properties":[{"key":"ProteinId","value":"CAA53455.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U07550","properties":[{"key":"ProteinId","value":"AAA50953.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ250915","properties":[{"key":"ProteinId","value":"CAB75425.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK312104","properties":[{"key":"ProteinId","value":"BAG35040.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR407688","properties":[{"key":"ProteinId","value":"CAG28616.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC020550","properties":[{"key":"ProteinId","value":"AAX93146.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471063","properties":[{"key":"ProteinId","value":"EAW70163.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC023518","properties":[{"key":"ProteinId","value":"AAH23518.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AH007060","properties":[{"key":"ProteinId","value":"AAC95387.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS2320.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"S47532","properties":[{"key":"EntryName","value":"S47532"}]},{"database":"RefSeq","id":"NP_002148.1","properties":[{"key":"NucleotideSequenceId","value":"NM_002157.3"}]},{"database":"PDB","id":"4PJ1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.15 A"},{"key":"Chains","value":"1/2/O/P/Q/R/S/T/U/V/W/X/Y/Z=1-102"}]},{"database":"PDB","id":"6HT7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"1/2/O/P/Q/R/S/T/U/V/W/X/Y/Z=1-102"}]},{"database":"PDB","id":"6MRC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.08 A"},{"key":"Chains","value":"1/2/O/P/Q/R/S/T/U/V/W/X/Y/Z=3-102"}]},{"database":"PDB","id":"6MRD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.82 A"},{"key":"Chains","value":"O/P/Q/R/S/T/U=3-102"}]},{"database":"PDB","id":"8G7N","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"1/2/M/O/P/Q/R/S/T/U/V/W/X/Z=1-102"}]},{"database":"PDB","id":"8G7O","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"H/I/J/K/L/M/N=3-102"}]},{"database":"PDB","id":"9ES0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.58 A"},{"key":"Chains","value":"a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-102"}]},{"database":"PDB","id":"9ES1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"a/b/c/d/e/f/g=1-102"}]},{"database":"PDB","id":"9ES4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.91 A"},{"key":"Chains","value":"a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-102"}]},{"database":"PDB","id":"9ES5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"a/b/c/d/e/f/g=1-102"}]},{"database":"PDB","id":"9H5S","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.98 A"},{"key":"Chains","value":"a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-102"}]},{"database":"PDB","id":"9H5T","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.44 A"},{"key":"Chains","value":"a/b/c/d/e/f/g=1-102"}]},{"database":"PDB","id":"9L8P","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"7.30 A"},{"key":"Chains","value":"1/2/M/O/P/Q/R/S/T/U/V/W/X/Z=1-102"}]},{"database":"PDB","id":"9SHG","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.91 A"},{"key":"Chains","value":"a/b/c/d/e/f/g/h/i/j/k/l/m/n=1-102"}]},{"database":"PDB","id":"9SHH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.11 A"},{"key":"Chains","value":"a/b/c/d/e/f/g=1-102"}]},{"database":"PDB","id":"9SHI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.19 A"},{"key":"Chains","value":"a/b/c/d/e/f/g=1-102"}]},{"database":"PDBsum","id":"4PJ1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6HT7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MRC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MRD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8G7N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8G7O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9ES0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9ES1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9ES4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9ES5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9H5S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9H5T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9L8P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9SHG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9SHH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9SHI","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-19930","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-19931","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-19934","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-19935","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29817","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29818","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-51890","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-51891","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54898","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54899","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54900","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-9195","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-9196","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109568","properties":[{"key":"Interactions","value":"326"}]},{"database":"FunCoup","id":"P61604","properties":[{"key":"Number of interactors","value":"1351"}]},{"database":"IntAct","id":"P61604","properties":[{"key":"Interactions","value":"119"}]},{"database":"MINT","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-HSPE1","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000233893","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3808268","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB12695","properties":[{"key":"GenericName","value":"Phenethyl Isothiocyanate"}]},{"database":"GlyCosmos","id":"P61604","properties":[{"key":"glycosylation","value":"1 site, 1 glycan"}]},{"database":"GlyGen","id":"P61604","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"HSPE1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"47606335","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000233893","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"57325","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3376","properties":[{"key":"antibodies","value":"530 antibodies from 39 providers"}]},{"database":"DNASU","id":"3336","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000233893.10","properties":[{"key":"ProteinId","value":"ENSP00000233893.5"},{"key":"GeneId","value":"ENSG00000115541.12"}]},{"database":"GeneID","id":"3336","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3336","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000233893.10","properties":[{"key":"ProteinId","value":"ENSP00000233893.5"},{"key":"RefSeqNucleotideId","value":"NM_002157.3"},{"key":"RefSeqProteinId","value":"NP_002148.1"}]},{"database":"UCSC","id":"uc002uul.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:5269","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA29535","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3336","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3336","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HSPE1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5269","properties":[{"key":"GeneName","value":"HSPE1"}]},{"database":"HPA","id":"ENSG00000115541","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (adrenal)"}]},{"database":"MIM","id":"600141","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000115541","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000115541","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1641","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000006350","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_132825_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"EDFLIMR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9525814at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P61604","properties":[{"key":"Number of GO annotations","value":"6 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9013408","properties":[{"key":"PathwayName","value":"RHOG GTPase cycle"}]},{"database":"Reactome","id":"R-HSA-9841251","properties":[{"key":"PathwayName","value":"Mitochondrial unfolded protein response (UPRmt)"}]},{"database":"SignaLink","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000115541","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3336","properties":[{"key":"hits","value":"731 hits in 1050 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"HSPE1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P61604","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"GroES","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3336","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P61604","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P61604","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"P61604","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000115541","properties":[{"key":"ExpressionPatterns","value":"Expressed in adrenal tissue and 101 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P61604","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"20458337"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"16210410"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10205158"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0044183","properties":[{"key":"GoTerm","value":"F:protein folding chaperone"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051087","properties":[{"key":"GoTerm","value":"F:protein-folding chaperone binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"10205158"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22658674"}]},{"database":"GO","id":"GO:0051082","properties":[{"key":"GoTerm","value":"F:unfolded protein binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0097193","properties":[{"key":"GoTerm","value":"P:intrinsic apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10205158"}]},{"database":"GO","id":"GO:0001649","properties":[{"key":"GoTerm","value":"P:osteoblast differentiation"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"16210410"}]},{"database":"GO","id":"GO:0006457","properties":[{"key":"GoTerm","value":"P:protein folding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006986","properties":[{"key":"GoTerm","value":"P:response to unfolded protein"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7698325"}]},{"database":"CDD","id":"cd00320","properties":[{"key":"EntryName","value":"cpn10"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.33.40:FF:000002","properties":[{"key":"EntryName","value":"10 kDa chaperonin, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.33.40","properties":[{"key":"EntryName","value":"GroES chaperonin"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00580","properties":[{"key":"EntryName","value":"CH10"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR020818","properties":[{"key":"EntryName","value":"Chaperonin_GroES"}]},{"database":"InterPro","id":"IPR037124","properties":[{"key":"EntryName","value":"Chaperonin_GroES_sf"}]},{"database":"InterPro","id":"IPR018369","properties":[{"key":"EntryName","value":"Chaprnonin_Cpn10_CS"}]},{"database":"InterPro","id":"IPR011032","properties":[{"key":"EntryName","value":"GroES-like_sf"}]},{"database":"PANTHER","id":"PTHR10772","properties":[{"key":"EntryName","value":"10 KDA HEAT SHOCK PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10772:SF0","properties":[{"key":"EntryName","value":"10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00166","properties":[{"key":"EntryName","value":"Cpn10"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00297","properties":[{"key":"EntryName","value":"CHAPERONIN10"}]},{"database":"SMART","id":"SM00883","properties":[{"key":"EntryName","value":"Cpn10"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50129","properties":[{"key":"EntryName","value":"GroES-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00681","properties":[{"key":"EntryName","value":"CHAPERONINS_CPN10"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQATVVAVGSGSKGKGGEIQPVSVKVGDKVLLPEYGGTKVVLDDKDYFLFRDGDILGKYVD","length":102,"molWeight":10932,"crc64":"1F3192C81F6EDB78","md5":"D53EC8777F58C2030BCCD6463F78814E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"INDUCTION":1,"MASS SPECTROMETRY":1,"SIMILARITY":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Modified residue":21,"Beta strand":10,"Helix":2,"Turn":1},"uniParcId":"UPI0000001C17"}}