{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P36776","secondaryAccessions":["B3KPH8","D6W635","E5KMH8","F5GZ27","P36777","Q8N8K8","Q9UQ95"],"uniProtkbId":"LONM_HUMAN","entryAudit":{"firstPublicDate":"1994-06-01","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2000-12-01","entryVersion":227,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"}],"value":"Lon protease homolog, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14739292"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17420247"}],"value":"3.4.21.53"}]},"alternativeNames":[{"fullName":{"value":"LONHs"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"}],"value":"Lon protease-like protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"}],"value":"LONP"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"}],"value":"Mitochondrial ATP-dependent protease Lon"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"33431889"}],"value":"Mitochondrial chaperone LONP1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33431889"}],"value":"3.6.4.10"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"}],"value":"Serine protease 15"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:9479"}],"value":"LONP1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"38688959"}],"value":"Lon"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:9479"}],"value":"PRSS15"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12198491"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14739292"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15870080"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17420247"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17579211"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28377575"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33431889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37327776"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8248235"}],"value":"ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix (PubMed:12198491, PubMed:15870080, PubMed:17579211, PubMed:37327776, PubMed:8248235, PubMed:35870450, PubMed:38688959). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m (PubMed:17579211, PubMed:28377575, PubMed:37327776). MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). In addtion to its protease activity, has also an ATP-dependent protein folding chaperone activity and functions in mitochondrial protein folding (PubMed:33431889). Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome (PubMed:17420247). Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner (PubMed:17420247). May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:14739292, PubMed:17420247)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Hydrolysis of proteins in presence of ATP.","ecNumber":"3.4.21.53","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14739292"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17420247"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33431889"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"33431889"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24520911"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"}],"value":"Peptidase activity is subject to substrate inhibition by ATP (PubMed:24520911). Inorganic polyphosphate (polyP) acts as a potent inhibitor (PubMed:38688959)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14739292"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20222013"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25369343"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27632940"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"}],"value":"Homohexamer (PubMed:14739292, PubMed:20222013, PubMed:25369343, PubMed:38688959, PubMed:35870450). Organized in a ring with a central cavity (PubMed:20222013, PubMed:25369343). The ATP-binding and proteolytic domains (AP-domain) form a hexameric chamber, while the N-terminal domain is arranged as a trimer of dimers (PubMed:27632940). DNA and RNA binding is stimulated by substrate and inhibited by ATP binding. Interacts with TWNK and mitochondrial DNA polymerase subunit POLG (PubMed:14739292)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P36776","intActId":"EBI-357448"},"interactantTwo":{"uniProtKBAccession":"Q4G176","geneName":"ACSF3","intActId":"EBI-10714818"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P36776","intActId":"EBI-357448"},"interactantTwo":{"uniProtKBAccession":"P02666","geneName":"CSN2","intActId":"EBI-5260183"},"numberOfExperiments":6,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P36776-1","intActId":"EBI-25473602"},"interactantTwo":{"uniProtKBAccession":"P36776-1","geneName":"LONP1","intActId":"EBI-25473602"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7961901"}],"value":"Mitochondrion matrix","id":"SL-0170"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P36776-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P36776-2"],"sequenceIds":["VSP_054617"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["P36776-3"],"sequenceIds":["VSP_055310"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8248235"}],"value":"Duodenum, heart, lung and liver, but not thymus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27632940"}],"value":"The Lon N-terminal domains are crucial for the overall structure of the protein, maintaining it in a conformation allowing its proper functioning"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27632940"}],"value":"The AP-domain (ATP-binding and proteolytic domains) has a closed-ring conformation in the presence of AMP-PNP and its N-terminal entry gate appears closed. Upon ADP binding, it switches to a lock-washer conformation and its N-terminal gate opens"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24520911"}],"value":"The proteolytic site is connected to the ATP binding site through the GG loop (Gly-893 and Gly-894) and the loop containing Trp-770. Binding of a protein substrate such as beta-casein appears to trigger movement of both these loops as part of the conformational changes which lead to enhanced ATPase and peptidase activities"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"}],"value":"Phosphorylated. Phosphorylation at Tyr-186 and Tyr-394 inhibits the ATP-dependent protease activity"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"CODAS syndrome","diseaseAccession":"DI-04347","acronym":"CODASS","description":"A rare syndrome characterized by the combination of cerebral, ocular, dental, auricular, and skeletal features. These include developmental delay, craniofacial anomalies, cataracts, ptosis, median nasal groove, delayed tooth eruption, hearing loss, short stature, delayed epiphyseal ossification, metaphyseal hip dysplasia, and vertebral coronal clefts.","diseaseCrossReference":{"database":"MIM","id":"600373"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25574826"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25808063"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33431889"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"}],"value":"Belongs to the peptidase S16 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAA52291.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Transit peptide","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Mitochondrion","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25944712"}]},{"type":"Chain","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":959,"modifier":"EXACT"}},"description":"Lon protease homolog, mitochondrial","featureId":"PRO_0000026734"},{"type":"Domain","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"Lon N-terminal","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01123"}]},{"type":"Domain","location":{"start":{"value":759,"modifier":"EXACT"},"end":{"value":949,"modifier":"EXACT"}},"description":"Lon proteolytic","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01122"}]},{"type":"Region","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":855,"modifier":"EXACT"},"end":{"value":855,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14739292"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24520911"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33431889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}]},{"type":"Active site","location":{"start":{"value":898,"modifier":"EXACT"},"end":{"value":898,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}]},{"type":"Binding site","location":{"start":{"value":491,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OJL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OKA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OM7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OVF"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":491,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616","note":"ligand shared between two neighboring subunits"}},{"type":"Binding site","location":{"start":{"value":492,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NFY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7OXO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OJL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OKA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OM7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OVF"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":492,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7P09"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7P0M"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616","note":"ligand shared between two neighboring subunits"}},{"type":"Binding site","location":{"start":{"value":526,"modifier":"EXACT"},"end":{"value":526,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NFY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7OXO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7P09"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7P0B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7P0M"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OJL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OKA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OM7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OVF"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":526,"modifier":"EXACT"},"end":{"value":526,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616","note":"ligand shared between two neighboring subunits"}},{"type":"Binding site","location":{"start":{"value":527,"modifier":"EXACT"},"end":{"value":527,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NFY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7P09"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7P0B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7P0M"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OJL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OKA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OM7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OVF"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":527,"modifier":"EXACT"},"end":{"value":527,"modifier":"EXACT"}},"description":"in chain a","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616","note":"ligand shared between two neighboring subunits"}},{"type":"Binding site","location":{"start":{"value":528,"modifier":"EXACT"},"end":{"value":528,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NFY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7OXO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OJL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OKA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OM7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OVF"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":528,"modifier":"EXACT"},"end":{"value":528,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616","note":"ligand shared between two neighboring subunits"}},{"type":"Binding site","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":529,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7OXO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OJL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OKA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OM7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OVF"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":529,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616","note":"ligand shared between two neighboring subunits"}},{"type":"Binding site","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NFY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7OXO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OJL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OKA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OM7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OVF"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616","note":"ligand shared between two neighboring subunits"}},{"type":"Binding site","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NFY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGC"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":531,"modifier":"EXACT"},"end":{"value":531,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7OXO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OJL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OKA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OM7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OVF"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":531,"modifier":"EXACT"},"end":{"value":531,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616","note":"ligand shared between two neighboring subunits"}},{"type":"Binding site","location":{"start":{"value":590,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":591,"modifier":"EXACT"},"end":{"value":591,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NFY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":614,"modifier":"EXACT"},"end":{"value":614,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616","note":"ligand shared between two neighboring subunits"}},{"type":"Binding site","location":{"start":{"value":640,"modifier":"EXACT"},"end":{"value":640,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616","note":"ligand shared between two neighboring subunits"}},{"type":"Binding site","location":{"start":{"value":652,"modifier":"EXACT"},"end":{"value":652,"modifier":"EXACT"}},"description":"in chain B","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616","note":"ligand shared between two neighboring subunits"}},{"type":"Binding site","location":{"start":{"value":661,"modifier":"EXACT"},"end":{"value":661,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NFY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7OXO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OJL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OKA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OM7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OVF"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":661,"modifier":"EXACT"},"end":{"value":661,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616","note":"ligand shared between two neighboring subunits"}},{"type":"Binding site","location":{"start":{"value":677,"modifier":"EXACT"},"end":{"value":677,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OJL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OKA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OVF"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":710,"modifier":"EXACT"},"end":{"value":710,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7OXO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OJL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OKA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OM7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OVF"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":710,"modifier":"EXACT"},"end":{"value":710,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616","note":"ligand shared between two neighboring subunits"}},{"type":"Binding site","location":{"start":{"value":713,"modifier":"EXACT"},"end":{"value":713,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OKA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OM7"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Modified residue","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"}]},{"type":"Modified residue","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_055310","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_054617","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"in dbSNP:rs34413649","featureCrossReferences":[{"database":"dbSNP","id":"rs34413649"}],"featureId":"VAR_051564","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"in dbSNP:rs11085147","featureCrossReferences":[{"database":"dbSNP","id":"rs11085147"}],"featureId":"VAR_051565","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":476,"modifier":"EXACT"},"end":{"value":476,"modifier":"EXACT"}},"description":"in CODASS","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25808063"}],"featureId":"VAR_073338","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":631,"modifier":"EXACT"},"end":{"value":631,"modifier":"EXACT"}},"description":"in CODASS; dbSNP:rs879255248","featureCrossReferences":[{"database":"dbSNP","id":"rs879255248"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25574826"}],"featureId":"VAR_073339","alternativeSequence":{"originalSequence":"S","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":670,"modifier":"EXACT"},"end":{"value":670,"modifier":"EXACT"}},"description":"in CODASS; dbSNP:rs770036526","featureCrossReferences":[{"database":"dbSNP","id":"rs770036526"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25808063"}],"featureId":"VAR_073340","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":672,"modifier":"EXACT"},"end":{"value":672,"modifier":"EXACT"}},"description":"in CODASS; dbSNP:rs777009012","featureCrossReferences":[{"database":"dbSNP","id":"rs777009012"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25808063"}],"featureId":"VAR_073341","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":676,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"in CODASS; dbSNP:rs879255247","featureCrossReferences":[{"database":"dbSNP","id":"rs879255247"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25574826"}],"featureId":"VAR_073342","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":679,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"in CODASS; dbSNP:rs549574673","featureCrossReferences":[{"database":"dbSNP","id":"rs549574673"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25808063"}],"featureId":"VAR_073343","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":721,"modifier":"EXACT"},"end":{"value":721,"modifier":"EXACT"}},"description":"in CODASS; decreased ATP-dependent protein folding chaperone activity; dbSNP:rs147588238","featureCrossReferences":[{"database":"dbSNP","id":"rs147588238"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25574826"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33431889"}],"featureId":"VAR_073344","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":724,"modifier":"EXACT"},"end":{"value":724,"modifier":"EXACT"}},"description":"in CODASS; dbSNP:rs879255249","featureCrossReferences":[{"database":"dbSNP","id":"rs879255249"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25574826"}],"featureId":"VAR_073345","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":749,"modifier":"EXACT"},"end":{"value":749,"modifier":"EXACT"}},"description":"in CODASS; dbSNP:rs2145578983","featureCrossReferences":[{"database":"dbSNP","id":"rs2145578983"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25808063"}],"featureId":"VAR_073346","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":767,"modifier":"EXACT"},"end":{"value":767,"modifier":"EXACT"}},"description":"in CODASS; dbSNP:rs562553348","featureCrossReferences":[{"database":"dbSNP","id":"rs562553348"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25808063"}],"featureId":"VAR_073347","alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":829,"modifier":"EXACT"},"end":{"value":829,"modifier":"EXACT"}},"description":"in dbSNP:rs35804229","featureCrossReferences":[{"database":"dbSNP","id":"rs35804229"}],"featureId":"VAR_067708","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":911,"modifier":"EXACT"},"end":{"value":911,"modifier":"EXACT"}},"description":"in dbSNP:rs1062373","featureCrossReferences":[{"database":"dbSNP","id":"rs1062373"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20843780"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8119403"}],"featureId":"VAR_067709","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":927,"modifier":"EXACT"},"end":{"value":927,"modifier":"EXACT"}},"description":"in CODASS","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25808063"}],"featureId":"VAR_073348","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Decreased protease activity. Decreased ATPase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Decreased protease activity. Decreased ATPase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38688959"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":520,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"No effect on protease activity. No effect on ATPase activity. Decrease protease activity and ATPase activity; when associated with S-637.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":529,"modifier":"EXACT"}},"description":"Loss of ATP-dependent protein folding chaperone activity. Dominant negative that induces protein aggregation in the mitochondria. Does not block access to the proteolytic active site or prevent a substrate from binding to it. Loss of ATPase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24520911"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33431889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":591,"modifier":"EXACT"},"end":{"value":591,"modifier":"EXACT"}},"description":"Loss of protease activity. Loss of ATPase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":637,"modifier":"EXACT"},"end":{"value":637,"modifier":"EXACT"}},"description":"Decreased protease activity and ATPase activity; when associated with S-520.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":770,"modifier":"EXACT"},"end":{"value":770,"modifier":"EXACT"}},"description":"Has low basal, but normal stimulated ATPase activity, and retains peptidase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24520911"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":770,"modifier":"EXACT"},"end":{"value":770,"modifier":"EXACT"}},"description":"Has normal basal, but low stimulated ATPase activity, and abolishes peptidase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24520911"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["P"]}},{"type":"Mutagenesis","location":{"start":{"value":801,"modifier":"EXACT"},"end":{"value":801,"modifier":"EXACT"}},"description":"Loss of protease activity. Decreased ATPase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":803,"modifier":"EXACT"},"end":{"value":803,"modifier":"EXACT"}},"description":"Loss of protease activity. Decreased ATPase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":812,"modifier":"EXACT"},"end":{"value":812,"modifier":"EXACT"}},"description":"Loss of protease activity. Decreased ATPase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":841,"modifier":"EXACT"},"end":{"value":841,"modifier":"EXACT"}},"description":"Loss of protease activity. Decreased ATPase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":843,"modifier":"EXACT"},"end":{"value":843,"modifier":"EXACT"}},"description":"Loss of protease activity. Decreased ATPase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":855,"modifier":"EXACT"},"end":{"value":855,"modifier":"EXACT"}},"description":"Loss of protease activity. No effect on DNA binding activity. Decreased chaperone activity. Decreased ATPase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14739292"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24520911"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33431889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35870450"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":880,"modifier":"EXACT"},"end":{"value":880,"modifier":"EXACT"}},"description":"Enhances the basal, but not the stimulated ATPase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24520911"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":893,"modifier":"EXACT"},"end":{"value":893,"modifier":"EXACT"}},"description":"Has low basal, but normal stimulated ATPase activity, and retains peptidase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24520911"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":893,"modifier":"EXACT"},"end":{"value":893,"modifier":"EXACT"}},"description":"Has normal basal, but low stimulated ATPase activity, and abolishes peptidase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24520911"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["P"]}},{"type":"Mutagenesis","location":{"start":{"value":894,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Enhances the basal, but not the stimulated ATPase activity, and retains peptidase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24520911"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A","S"]}},{"type":"Mutagenesis","location":{"start":{"value":894,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Enhances the basal, but not the stimulated ATPase activity, and abolishes peptidase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24520911"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"in Ref. 1; AAA61616","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASPPWALW","alternativeSequences":["MAGLWRRALATCDCGERRGAGCCGGRCWPRRGAGSHCSRSVVAPRPADLRRLSSLGTV"]}},{"type":"Sequence conflict","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"in Ref. 1; AAA61616","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"WR","alternativeSequences":["CG"]}},{"type":"Sequence conflict","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"in Ref. 1; AAA61616","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"EL","alternativeSequences":["DV"]}},{"type":"Sequence conflict","location":{"start":{"value":423,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"in Ref. 4; BAG51690","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":456,"modifier":"EXACT"},"end":{"value":456,"modifier":"EXACT"}},"description":"in Ref. 1; AAA61616","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":501,"modifier":"EXACT"}},"description":"in Ref. 4; BAG51690","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":556,"modifier":"EXACT"},"end":{"value":556,"modifier":"EXACT"}},"description":"in Ref. 1; AAA61616","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":842,"modifier":"EXACT"},"end":{"value":842,"modifier":"EXACT"}},"description":"in Ref. 1; AAA61616","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":859,"modifier":"EXACT"},"end":{"value":859,"modifier":"EXACT"}},"description":"in Ref. 1; AAA61616","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Helix","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Beta strand","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Helix","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Beta strand","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Beta strand","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Helix","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Beta strand","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Beta strand","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Beta strand","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Beta strand","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Helix","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Helix","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Helix","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Helix","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Helix","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Helix","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Turn","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9CC3"}]},{"type":"Helix","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":427,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":432,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Beta strand","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KSL"}]},{"type":"Helix","location":{"start":{"value":453,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P0M"}]},{"type":"Helix","location":{"start":{"value":480,"modifier":"EXACT"},"end":{"value":490,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Beta strand","location":{"start":{"value":518,"modifier":"EXACT"},"end":{"value":522,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Beta strand","location":{"start":{"value":525,"modifier":"EXACT"},"end":{"value":528,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Helix","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Beta strand","location":{"start":{"value":544,"modifier":"EXACT"},"end":{"value":548,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":556,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Beta strand","location":{"start":{"value":565,"modifier":"EXACT"},"end":{"value":567,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KSL"}]},{"type":"Helix","location":{"start":{"value":572,"modifier":"EXACT"},"end":{"value":580,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Beta strand","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":584,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Beta strand","location":{"start":{"value":586,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":592,"modifier":"EXACT"},"end":{"value":594,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Beta strand","location":{"start":{"value":599,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":603,"modifier":"EXACT"},"end":{"value":611,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":613,"modifier":"EXACT"},"end":{"value":616,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Beta strand","location":{"start":{"value":617,"modifier":"EXACT"},"end":{"value":620,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P0M"}]},{"type":"Turn","location":{"start":{"value":622,"modifier":"EXACT"},"end":{"value":624,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P0M"}]},{"type":"Beta strand","location":{"start":{"value":626,"modifier":"EXACT"},"end":{"value":628,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P0M"}]},{"type":"Helix","location":{"start":{"value":630,"modifier":"EXACT"},"end":{"value":632,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9CC3"}]},{"type":"Beta strand","location":{"start":{"value":634,"modifier":"EXACT"},"end":{"value":640,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":644,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KRZ"}]},{"type":"Helix","location":{"start":{"value":647,"modifier":"EXACT"},"end":{"value":651,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Beta strand","location":{"start":{"value":653,"modifier":"EXACT"},"end":{"value":657,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":663,"modifier":"EXACT"},"end":{"value":669,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":670,"modifier":"EXACT"},"end":{"value":674,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":675,"modifier":"EXACT"},"end":{"value":682,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Turn","location":{"start":{"value":686,"modifier":"EXACT"},"end":{"value":688,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":693,"modifier":"EXACT"},"end":{"value":702,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Beta strand","location":{"start":{"value":706,"modifier":"EXACT"},"end":{"value":709,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":712,"modifier":"EXACT"},"end":{"value":729,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Beta strand","location":{"start":{"value":733,"modifier":"EXACT"},"end":{"value":736,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":739,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Helix","location":{"start":{"value":742,"modifier":"EXACT"},"end":{"value":746,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P09"}]},{"type":"Beta strand","location":{"start":{"value":750,"modifier":"EXACT"},"end":{"value":753,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KSL"}]},{"type":"Beta strand","location":{"start":{"value":754,"modifier":"EXACT"},"end":{"value":756,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OJL"}]},{"type":"Beta strand","location":{"start":{"value":764,"modifier":"EXACT"},"end":{"value":786,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Beta strand","location":{"start":{"value":799,"modifier":"EXACT"},"end":{"value":804,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Helix","location":{"start":{"value":808,"modifier":"EXACT"},"end":{"value":828,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Helix","location":{"start":{"value":834,"modifier":"EXACT"},"end":{"value":837,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Beta strand","location":{"start":{"value":839,"modifier":"EXACT"},"end":{"value":843,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Turn","location":{"start":{"value":850,"modifier":"EXACT"},"end":{"value":852,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Helix","location":{"start":{"value":853,"modifier":"EXACT"},"end":{"value":856,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Helix","location":{"start":{"value":857,"modifier":"EXACT"},"end":{"value":869,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Helix","location":{"start":{"value":872,"modifier":"EXACT"},"end":{"value":874,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Beta strand","location":{"start":{"value":877,"modifier":"EXACT"},"end":{"value":879,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Beta strand","location":{"start":{"value":887,"modifier":"EXACT"},"end":{"value":890,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Helix","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":904,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Beta strand","location":{"start":{"value":909,"modifier":"EXACT"},"end":{"value":913,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Helix","location":{"start":{"value":914,"modifier":"EXACT"},"end":{"value":916,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Helix","location":{"start":{"value":917,"modifier":"EXACT"},"end":{"value":921,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Helix","location":{"start":{"value":925,"modifier":"EXACT"},"end":{"value":928,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Beta strand","location":{"start":{"value":932,"modifier":"EXACT"},"end":{"value":938,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Helix","location":{"start":{"value":939,"modifier":"EXACT"},"end":{"value":946,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2X36"}]},{"type":"Helix","location":{"start":{"value":948,"modifier":"EXACT"},"end":{"value":951,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6WZV"}]},{"type":"Helix","location":{"start":{"value":952,"modifier":"EXACT"},"end":{"value":956,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6X27"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0898","category":"Disease","name":"Cataract"},{"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"id":"KW-0209","category":"Disease","name":"Deafness"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0242","category":"Disease","name":"Dwarfism"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0645","category":"Molecular function","name":"Protease"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0720","category":"Molecular function","name":"Serine protease"},{"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"8248235","citationType":"journal article","authors":["Wang N.","Gottesman S.","Willingham M.C.","Gottesman M.M.","Maurizi M.R."],"citationCrossReferences":[{"database":"PubMed","id":"8248235"},{"database":"DOI","id":"10.1073/pnas.90.23.11247"}],"title":"A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease.","publicationDate":"1993","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"11247","lastPage":"11251","volume":"90"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"20843780","citationType":"journal article","authors":["Wang W.","Shen P.","Thiyagarajan S.","Lin S.","Palm C.","Horvath R.","Klopstock T.","Cutler D.","Pique L.","Schrijver I.","Davis R.W.","Mindrinos M.","Speed T.P.","Scharfe C."],"citationCrossReferences":[{"database":"PubMed","id":"20843780"},{"database":"DOI","id":"10.1093/nar/gkq750"}],"title":"Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.","publicationDate":"2011","journal":"Nucleic Acids Res.","firstPage":"44","lastPage":"58","volume":"39"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT ILE-911"]},{"referenceNumber":3,"citation":{"id":"CI-5I49CRKQFDJQH","citationType":"submission","authors":["Huang N.N.","Maurizi M.R.","Torres R.R.","Polymeropoulos M.H.","Lennon G.G.","Gottesman M.M."],"title":"Chromosomal mapping and genomic organization of the ATP-dependent human LON protease gene.","publicationDate":"APR-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.S.","Terry A.","Schmutz J.","Lamerdin J.E.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.V.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.-H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.M.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Eye","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"8119403","citationType":"journal article","authors":["Amerik A.Y.","Petukhova G.V.","Grigorenko V.G.","Lykov I.P.","Yarovoi S.V.","Lipkin V.M.","Gorbalenya A.E."],"citationCrossReferences":[{"database":"PubMed","id":"8119403"},{"database":"DOI","id":"10.1016/0014-5793(94)80166-5"}],"title":"Cloning and sequence analysis of cDNA for a human homolog of eubacterial ATP-dependent Lon proteases.","publicationDate":"1994","journal":"FEBS Lett.","firstPage":"25","lastPage":"28","volume":"340"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 3-959 (ISOFORM 1)","VARIANT ILE-911"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"7961901","citationType":"journal article","authors":["Wang N.","Maurizi M.R.","Emmert-Buck L.","Gottesman M.M."],"citationCrossReferences":[{"database":"PubMed","id":"7961901"},{"database":"DOI","id":"10.1016/s0021-9258(19)62045-4"}],"title":"Synthesis, processing, and localization of human Lon protease.","publicationDate":"1994","journal":"J. Biol. Chem.","firstPage":"29308","lastPage":"29313","volume":"269"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":10,"citation":{"id":"9485316","citationType":"journal article","authors":["Fu G.K.","Markovitz D.M."],"citationCrossReferences":[{"database":"PubMed","id":"9485316"},{"database":"DOI","id":"10.1021/bi970928c"}],"title":"The human LON protease binds to mitochondrial promoters in a single-stranded, site-specific, strand-specific manner.","publicationDate":"1998","journal":"Biochemistry","firstPage":"1905","lastPage":"1909","volume":"37"},"referencePositions":["DNA-BINDING"]},{"referenceNumber":11,"citation":{"id":"12198491","citationType":"journal article","authors":["Bota D.A.","Davies K.J."],"citationCrossReferences":[{"database":"PubMed","id":"12198491"},{"database":"DOI","id":"10.1038/ncb836"}],"title":"Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism.","publicationDate":"2002","journal":"Nat. Cell Biol.","firstPage":"674","lastPage":"680","volume":"4"},"referencePositions":["FUNCTION"]},{"referenceNumber":12,"citation":{"id":"14739292","citationType":"journal article","authors":["Liu T.","Lu B.","Lee I.","Ondrovicova G.","Kutejova E.","Suzuki C.K."],"citationCrossReferences":[{"database":"PubMed","id":"14739292"},{"database":"DOI","id":"10.1074/jbc.m309642200"}],"title":"DNA and RNA binding by the mitochondrial lon protease is regulated by nucleotide and protein substrate.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"13902","lastPage":"13910","volume":"279"},"referencePositions":["DNA-BINDING","FUNCTION","CATALYTIC ACTIVITY","MUTAGENESIS OF SER-855","SUBUNIT","INTERACTION WITH TWNK AND POLG"]},{"referenceNumber":13,"citation":{"id":"15870080","citationType":"journal article","authors":["Ondrovicova G.","Liu T.","Singh K.","Tian B.","Li H.","Gakh O.","Perecko D.","Janata J.","Granot Z.","Orly J.","Kutejova E.","Suzuki C.K."],"citationCrossReferences":[{"database":"PubMed","id":"15870080"},{"database":"DOI","id":"10.1074/jbc.m502796200"}],"title":"Cleavage site selection within a folded substrate by the ATP-dependent lon protease.","publicationDate":"2005","journal":"J. Biol. Chem.","firstPage":"25103","lastPage":"25110","volume":"280"},"referencePositions":["FUNCTION"]},{"referenceNumber":14,"citation":{"id":"17420247","citationType":"journal article","authors":["Lu B.","Yadav S.","Shah P.G.","Liu T.","Tian B.","Pukszta S.","Villaluna N.","Kutejova E.","Newlon C.S.","Santos J.H.","Suzuki C.K."],"citationCrossReferences":[{"database":"PubMed","id":"17420247"},{"database":"DOI","id":"10.1074/jbc.m611540200"}],"title":"Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance.","publicationDate":"2007","journal":"J. Biol. Chem.","firstPage":"17363","lastPage":"17374","volume":"282"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","DNA-BINDING"]},{"referenceNumber":15,"citation":{"id":"17579211","citationType":"journal article","authors":["Granot Z.","Kobiler O.","Melamed-Book N.","Eimerl S.","Bahat A.","Lu B.","Braun S.","Maurizi M.R.","Suzuki C.K.","Oppenheim A.B.","Orly J."],"citationCrossReferences":[{"database":"PubMed","id":"17579211"},{"database":"DOI","id":"10.1210/me.2005-0458"}],"title":"Turnover of mitochondrial steroidogenic acute regulatory (StAR) protein by Lon protease: the unexpected effect of proteasome inhibitors.","publicationDate":"2007","journal":"Mol. Endocrinol.","firstPage":"2164","lastPage":"2177","volume":"21"},"referencePositions":["FUNCTION"]},{"referenceNumber":16,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":17,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"24520911","citationType":"journal article","authors":["Ambro L.","Pevala V.","Ondrovicova G.","Bellova J.","Kunova N.","Kutejova E.","Bauer J."],"citationCrossReferences":[{"database":"PubMed","id":"24520911"},{"database":"DOI","id":"10.1111/febs.12740"}],"title":"Mutations to a glycine loop in the catalytic site of human Lon changes its protease, peptidase and ATPase activities.","publicationDate":"2014","journal":"FEBS J.","firstPage":"1784","lastPage":"1797","volume":"281"},"referencePositions":["MUTAGENESIS OF LYS-529; TRP-770; SER-855; THR-880; GLY-893 AND GLY-894"]},{"referenceNumber":19,"citation":{"id":"25369343","citationType":"journal article","authors":["Kereiche S.","Kovacik L.","Pevala V.","Ambro L.","Bellova J.","Kutejova E.","Raska I."],"citationCrossReferences":[{"database":"PubMed","id":"25369343"},{"database":"DOI","id":"10.14712/fb2014060s10062"}],"title":"Three-dimensional reconstruction of the S885A mutant of human mitochondrial Lon protease.","publicationDate":"2014","journal":"Folia Biol. (Praha)","firstPage":"62","lastPage":"65","volume":"60"},"referencePositions":["SUBUNIT"]},{"referenceNumber":20,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":21,"citation":{"id":"25574826","citationType":"journal article","authors":["Strauss K.A.","Jinks R.N.","Puffenberger E.G.","Venkatesh S.","Singh K.","Cheng I.","Mikita N.","Thilagavathi J.","Lee J.","Sarafianos S.","Benkert A.","Koehler A.","Zhu A.","Trovillion V.","McGlincy M.","Morlet T.","Deardorff M.","Innes A.M.","Prasad C.","Chudley A.E.","Lee I.N.","Suzuki C.K."],"citationCrossReferences":[{"database":"PubMed","id":"25574826"},{"database":"DOI","id":"10.1016/j.ajhg.2014.12.003"}],"title":"CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease.","publicationDate":"2015","journal":"Am. J. Hum. Genet.","firstPage":"121","lastPage":"135","volume":"96"},"referencePositions":["INVOLVEMENT IN CODASS","VARIANTS CODASS TYR-631; SER-676; GLY-721 AND VAL-724"]},{"referenceNumber":22,"citation":{"id":"25808063","citationType":"journal article","authors":["Dikoglu E.","Alfaiz A.","Gorna M.","Bertola D.","Chae J.H.","Cho T.J.","Derbent M.","Alanay Y.","Guran T.","Kim O.H.","Llerenar J.C. Jr.","Yamamoto G.","Superti-Furga G.","Reymond A.","Xenarios I.","Stevenson B.","Campos-Xavier B.","Bonafe L.","Superti-Furga A.","Unger S."],"citationCrossReferences":[{"database":"PubMed","id":"25808063"},{"database":"DOI","id":"10.1002/ajmg.a.37029"}],"title":"Mutations in LONP1, a mitochondrial matrix protease, cause CODAS syndrome.","publicationDate":"2015","journal":"Am. J. Med. Genet. A","firstPage":"1501","lastPage":"1509","volume":"167"},"referencePositions":["INVOLVEMENT IN CODASS","VARIANTS CODASS ALA-476; VAL-670; CYS-672; HIS-679; SER-749; GLU-767 AND ILE-927 DEL"]},{"referenceNumber":23,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["CLEAVAGE OF TRANSIT PEPTIDE [LARGE SCALE ANALYSIS] AFTER GLY-67","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":24,"citation":{"id":"28377575","citationType":"journal article","authors":["Kunova N.","Ondrovicova G.","Bauer J.A.","Bellova J.","Ambro L.","Martinakova L.","Kotrasova V.","Kutejova E.","Pevala V."],"citationCrossReferences":[{"database":"PubMed","id":"28377575"},{"database":"DOI","id":"10.1038/s41598-017-00632-8"}],"title":"The role of Lon-mediated proteolysis in the dynamics of mitochondrial nucleic acid-protein complexes.","publicationDate":"2017","journal":"Sci. Rep.","firstPage":"631","lastPage":"631","volume":"7"},"referencePositions":["FUNCTION"]},{"referenceNumber":25,"citation":{"id":"33431889","citationType":"journal article","authors":["Shin C.S.","Meng S.","Garbis S.D.","Moradian A.","Taylor R.W.","Sweredoski M.J.","Lomenick B.","Chan D.C."],"citationCrossReferences":[{"database":"PubMed","id":"33431889"},{"database":"DOI","id":"10.1038/s41467-020-20597-z"}],"title":"LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding.","publicationDate":"2021","journal":"Nat. Commun.","firstPage":"265","lastPage":"265","volume":"12"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","MUTAGENESIS OF LYS-529 AND SER-855","CHARACTERIZATION OF VARIANT CODASS GLY-721","ACTIVE SITE"]},{"referenceNumber":26,"citation":{"id":"37327776","citationType":"journal article","authors":["Sekine Y.","Houston R.","Eckl E.M.","Fessler E.","Narendra D.P.","Jae L.T.","Sekine S."],"citationCrossReferences":[{"database":"PubMed","id":"37327776"},{"database":"DOI","id":"10.1016/j.molcel.2023.05.031"}],"title":"A mitochondrial iron-responsive pathway regulated by DELE1.","publicationDate":"2023","journal":"Mol. Cell","firstPage":"2059","lastPage":"2076","volume":"83"},"referencePositions":["FUNCTION"]},{"referenceNumber":27,"citation":{"id":"20222013","citationType":"journal article","authors":["Garcia-Nafria J.","Ondrovicova G.","Blagova E.","Levdikov V.M.","Bauer J.A.","Suzuki C.K.","Kutejova E.","Wilkinson A.J.","Wilson K.S."],"citationCrossReferences":[{"database":"PubMed","id":"20222013"},{"database":"DOI","id":"10.1002/pro.376"}],"title":"Structure of the catalytic domain of the human mitochondrial Lon protease: proposed relation of oligomer formation and activity.","publicationDate":"2010","journal":"Protein Sci.","firstPage":"987","lastPage":"999","volume":"19"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 753-959","SUBUNIT"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"2X36"}]},{"referenceNumber":28,"citation":{"id":"27632940","citationType":"journal article","authors":["Kereiche S.","Kovacik L.","Bednar J.","Pevala V.","Kunova N.","Ondrovicova G.","Bauer J.","Ambro L.","Bellova J.","Kutejova E.","Raska I."],"citationCrossReferences":[{"database":"PubMed","id":"27632940"},{"database":"DOI","id":"10.1038/srep33631"}],"title":"The N-terminal domain plays a crucial role in the structure of a full-length human mitochondrial Lon protease.","publicationDate":"2016","journal":"Sci. Rep.","firstPage":"33631","lastPage":"33631","volume":"6"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (15 ANGSTROMS) OF MUTANT ALA-855","SUBUNIT","DOMAIN"]},{"referenceNumber":29,"citation":{"id":"35870450","citationType":"journal article","authors":["Mohammed I.","Schmitz K.A.","Schenck N.","Balasopoulos D.","Topitsch A.","Maier T.","Abrahams J.P."],"citationCrossReferences":[{"database":"PubMed","id":"35870450"},{"database":"DOI","id":"10.1016/j.str.2022.06.006"}],"title":"Catalytic cycling of human mitochondrial Lon protease.","publicationDate":"2022","journal":"Structure","firstPage":"1254","lastPage":"1268.e7","volume":"30"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.80 ANGSTROMS) OF 115-959 IN COMPLEX WITH ADP; ATP AND MG(2+)","FUNCTION","CATALYTIC ACTIVITY","SUBUNIT","COFACTOR","MUTAGENESIS OF CYS-520; LYS-529; GLU-591; CYS-637; GLU-801; THR-803; GLU-812; HIS-841; HIS-843 AND SER-855","ACTIVE SITE"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NFY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NG5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7NGQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7OXO"}]},{"referenceNumber":30,"citation":{"id":"38688959","citationType":"journal article","authors":["Kunova N.","Ondrovicova G.","Bauer J.A.","Krajcovicova V.","Pinkas M.","Stojkovicova B.","Havalova H.","Lukacova V.","Kohutova L.","Kostan J.","Martinakova L.","Barath P.","Novacek J.","Zoll S.","Kereiche S.","Kutejova E.","Pevala V."],"citationCrossReferences":[{"database":"PubMed","id":"38688959"},{"database":"DOI","id":"10.1038/s41598-024-60030-9"}],"title":"Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions.","publicationDate":"2024","journal":"Sci. Rep.","firstPage":"9923","lastPage":"9923","volume":"14"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.88 ANGSTROMS) OF 121-959 IN COMPLEX WITH ADP","FUNCTION","ACTIVITY REGULATION","SUBUNIT","PHOSPHORYLATION AT TYR-186 AND TYR-394","MUTAGENESIS OF TYR-186 AND TYR-394"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OJL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OKA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OM7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OVF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8OVG"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U02389","properties":[{"key":"ProteinId","value":"AAA61616.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"HQ204946","properties":[{"key":"ProteinId","value":"ADP90374.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204947","properties":[{"key":"ProteinId","value":"ADP90375.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204948","properties":[{"key":"ProteinId","value":"ADP90376.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204949","properties":[{"key":"ProteinId","value":"ADP90377.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204950","properties":[{"key":"ProteinId","value":"ADP90378.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204951","properties":[{"key":"ProteinId","value":"ADP90379.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204952","properties":[{"key":"ProteinId","value":"ADP90380.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204953","properties":[{"key":"ProteinId","value":"ADP90381.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204954","properties":[{"key":"ProteinId","value":"ADP90382.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204955","properties":[{"key":"ProteinId","value":"ADP90383.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204956","properties":[{"key":"ProteinId","value":"ADP90384.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204957","properties":[{"key":"ProteinId","value":"ADP90385.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204958","properties":[{"key":"ProteinId","value":"ADP90386.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204959","properties":[{"key":"ProteinId","value":"ADP90387.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204960","properties":[{"key":"ProteinId","value":"ADP90388.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204961","properties":[{"key":"ProteinId","value":"ADP90389.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204962","properties":[{"key":"ProteinId","value":"ADP90390.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204963","properties":[{"key":"ProteinId","value":"ADP90391.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204964","properties":[{"key":"ProteinId","value":"ADP90392.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204965","properties":[{"key":"ProteinId","value":"ADP90393.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204966","properties":[{"key":"ProteinId","value":"ADP90394.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204968","properties":[{"key":"ProteinId","value":"ADP90396.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204969","properties":[{"key":"ProteinId","value":"ADP90397.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204970","properties":[{"key":"ProteinId","value":"ADP90398.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204971","properties":[{"key":"ProteinId","value":"ADP90399.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204972","properties":[{"key":"ProteinId","value":"ADP90400.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204973","properties":[{"key":"ProteinId","value":"ADP90401.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204974","properties":[{"key":"ProteinId","value":"ADP90402.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204975","properties":[{"key":"ProteinId","value":"ADP90403.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204976","properties":[{"key":"ProteinId","value":"ADP90404.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204977","properties":[{"key":"ProteinId","value":"ADP90405.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204978","properties":[{"key":"ProteinId","value":"ADP90406.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204979","properties":[{"key":"ProteinId","value":"ADP90407.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204980","properties":[{"key":"ProteinId","value":"ADP90408.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204981","properties":[{"key":"ProteinId","value":"ADP90409.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204982","properties":[{"key":"ProteinId","value":"ADP90410.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204983","properties":[{"key":"ProteinId","value":"ADP90411.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204984","properties":[{"key":"ProteinId","value":"ADP90412.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ204985","properties":[{"key":"ProteinId","value":"ADP90413.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059309","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059296","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059297","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059298","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059299","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059300","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059301","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059302","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059303","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059304","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059305","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059306","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059307","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF059308","properties":[{"key":"ProteinId","value":"AAD24414.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK056366","properties":[{"key":"ProteinId","value":"BAG51690.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK096626","properties":[{"key":"ProteinId","value":"BAC04829.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC011499","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471139","properties":[{"key":"ProteinId","value":"EAW69151.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471139","properties":[{"key":"ProteinId","value":"EAW69154.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC000235","properties":[{"key":"ProteinId","value":"AAH00235.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X74215","properties":[{"key":"ProteinId","value":"CAA52291.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X76040","properties":[{"key":"ProteinId","value":"CAA53625.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS12148.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P36776-1"},{"database":"CCDS","id":"CCDS62507.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P36776-3"},{"database":"CCDS","id":"CCDS62508.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P36776-2"},{"database":"PIR","id":"S42366","properties":[{"key":"EntryName","value":"S42366"}]},{"database":"PIR","id":"S57342","properties":[{"key":"EntryName","value":"S57342"}]},{"database":"RefSeq","id":"NP_001263408.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001276479.2"}],"isoformId":"P36776-2"},{"database":"RefSeq","id":"NP_001263409.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001276480.1"}],"isoformId":"P36776-3"},{"database":"RefSeq","id":"NP_004784.2","properties":[{"key":"NucleotideSequenceId","value":"NM_004793.3"}],"isoformId":"P36776-1"},{"database":"PDB","id":"2X36","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D/E/F=753-959"}]},{"database":"PDB","id":"6WYS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.23 A"},{"key":"Chains","value":"A/B/C=754-959"}]},{"database":"PDB","id":"6WZV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.51 A"},{"key":"Chains","value":"A/B/C=754-959"}]},{"database":"PDB","id":"6X1M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.51 A"},{"key":"Chains","value":"A/B/C=754-959"}]},{"database":"PDB","id":"6X27","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.12 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=754-959"}]},{"database":"PDB","id":"7KRZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/B/C/D/E/F=414-947"}]},{"database":"PDB","id":"7KSL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"A/B/C/E/F=421-947"}]},{"database":"PDB","id":"7KSM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/B/C/D/E/F=416-947"}]},{"database":"PDB","id":"7NFY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"A/B/C/D/E/F=115-959"}]},{"database":"PDB","id":"7NG4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.40 A"},{"key":"Chains","value":"A/B/C/D/E/F=115-959"}]},{"database":"PDB","id":"7NG5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"A/B/C/D/E/F=115-959"}]},{"database":"PDB","id":"7NGC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"7.50 A"},{"key":"Chains","value":"A/B/C/D/E/F=123-948"}]},{"database":"PDB","id":"7NGF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.60 A"},{"key":"Chains","value":"A/B/C/D/E/F=123-948"}]},{"database":"PDB","id":"7NGL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"A/B/C/D/E/F=123-948"}]},{"database":"PDB","id":"7NGP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"15.00 A"},{"key":"Chains","value":"A/B/C/D/E/F=123-948"}]},{"database":"PDB","id":"7NGQ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"12.00 A"},{"key":"Chains","value":"A/B/C/D/E/F=123-948"}]},{"database":"PDB","id":"7OXO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"A/B/C/D/E/F=1-959"}]},{"database":"PDB","id":"7P09","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B/C/D/E/F=67-949"}]},{"database":"PDB","id":"7P0B","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"A/B/C/D/E/F=67-949"}]},{"database":"PDB","id":"7P0M","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.75 A"},{"key":"Chains","value":"A/B/C/D/E/F=67-959"}]},{"database":"PDB","id":"8OJL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.88 A"},{"key":"Chains","value":"A/B/C/D/E/F=121-959"}]},{"database":"PDB","id":"8OKA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.89 A"},{"key":"Chains","value":"A/B/C/D/E/F=115-959"}]},{"database":"PDB","id":"8OM7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.74 A"},{"key":"Chains","value":"A/B/C/D/E/F=115-959"}]},{"database":"PDB","id":"8OVF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"7.23 A"},{"key":"Chains","value":"A/B/C/D/E/F=115-959"}]},{"database":"PDB","id":"8OVG","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"8.47 A"},{"key":"Chains","value":"A/B/C/D/E/F=115-959"}]},{"database":"PDB","id":"9CC0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.31 A"},{"key":"Chains","value":"A/B/C/D/E/F=115-959"}]},{"database":"PDB","id":"9CC1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.92 A"},{"key":"Chains","value":"A/B/C/D/E/F=115-959"}]},{"database":"PDB","id":"9CC3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.23 A"},{"key":"Chains","value":"A/B/C/D/E/F=115-959"}]},{"database":"PDBsum","id":"2X36","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6WYS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6WZV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X1M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X27","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KRZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KSL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KSM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7NFY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7NG4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7NG5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7NGC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7NGF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7NGL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7NGP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7NGQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7OXO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7P09","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7P0B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7P0M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8OJL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8OKA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8OM7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8OVF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8OVG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9CC0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9CC1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9CC3","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12306","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12307","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12308","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12312","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12313","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12315","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12316","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12317","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-13102","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-13146","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-13147","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-13148","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16915","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16923","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16970","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17213","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17214","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23013","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23019","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23020","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23320","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-3274","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-3275","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-45430","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-45431","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-45433","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-45434","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"114762","properties":[{"key":"Interactions","value":"515"}]},{"database":"FunCoup","id":"P36776","properties":[{"key":"Number of interactors","value":"2738"}]},{"database":"IntAct","id":"P36776","properties":[{"key":"Interactions","value":"198"}]},{"database":"MINT","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-LONP1","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000353826","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4879436","properties":[{"key":"Description","value":"-"}]},{"database":"DrugCentral","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"3180","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"S16.002","properties":[{"key":"Description","value":"-"}]},{"database":"MoonDB","id":"P36776","properties":[{"key":"Type","value":"Curated"}]},{"database":"GlyGen","id":"P36776","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"LONP1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"12644239","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000353826","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"24918","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"55221","properties":[{"key":"Description","value":"-"}],"isoformId":"P36776-1"},{"database":"Pumba","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"811","properties":[{"key":"antibodies","value":"300 antibodies from 30 providers"}]},{"database":"DNASU","id":"9361","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000360614.8","properties":[{"key":"ProteinId","value":"ENSP00000353826.2"},{"key":"GeneId","value":"ENSG00000196365.13"}],"isoformId":"P36776-1"},{"database":"Ensembl","id":"ENST00000540670.6","properties":[{"key":"ProteinId","value":"ENSP00000441523.1"},{"key":"GeneId","value":"ENSG00000196365.13"}],"isoformId":"P36776-3"},{"database":"Ensembl","id":"ENST00000593119.5","properties":[{"key":"ProteinId","value":"ENSP00000468541.1"},{"key":"GeneId","value":"ENSG00000196365.13"}],"isoformId":"P36776-2"},{"database":"GeneID","id":"9361","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:9361","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000360614.8","properties":[{"key":"ProteinId","value":"ENSP00000353826.2"},{"key":"RefSeqNucleotideId","value":"NM_004793.4"},{"key":"RefSeqProteinId","value":"NP_004784.2"}]},{"database":"UCSC","id":"uc002mcx.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P36776-1"},{"database":"AGR","id":"HGNC:9479","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162394145","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"9361","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"9361","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"LONP1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:9479","properties":[{"key":"GeneName","value":"LONP1"}]},{"database":"HPA","id":"ENSG00000196365","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (adrenal)"}]},{"database":"MalaCards","id":"LONP1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"600373","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"605490","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000196365","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"1458","properties":[{"key":"Disease","value":"CODAS syndrome"}]},{"database":"Orphanet","id":"2140","properties":[{"key":"Disease","value":"Congenital diaphragmatic hernia"}]},{"database":"Orphanet","id":"79243","properties":[{"key":"Disease","value":"Pyruvate dehydrogenase E1-alpha deficiency"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000196365","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2004","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00530000063553","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_004109_1_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WLTNIPW","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2411602at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P36776","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.4.21.53","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9837999","properties":[{"key":"PathwayName","value":"Mitochondrial protein degradation"}]},{"database":"Reactome","id":"R-HSA-9841251","properties":[{"key":"PathwayName","value":"Mitochondrial unfolded protein response (UPRmt)"}]},{"database":"SignaLink","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000196365","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"9361","properties":[{"key":"hits","value":"817 hits in 1165 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"LONP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P36776","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"LONP1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"9361","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P36776","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P36776","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"RNAct","id":"P36776","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000196365","properties":[{"key":"ExpressionPatterns","value":"Expressed in right adrenal gland and 193 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P36776","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12198491"}]},{"database":"GO","id":"GO:0042645","properties":[{"key":"GoTerm","value":"C:mitochondrial nucleoid"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18063578"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8248235"}]},{"database":"GO","id":"GO:0043531","properties":[{"key":"GoTerm","value":"F:ADP binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14739292"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14739292"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0004176","properties":[{"key":"GoTerm","value":"F:ATP-dependent peptidase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17420247"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37327776"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8248235"}]},{"database":"GO","id":"GO:0070182","properties":[{"key":"GoTerm","value":"F:DNA polymerase binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"14739292"}]},{"database":"GO","id":"GO:0051880","properties":[{"key":"GoTerm","value":"F:G-quadruplex DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18174225"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"14739292"}]},{"database":"GO","id":"GO:0043560","properties":[{"key":"GoTerm","value":"F:insulin receptor substrate binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042731","properties":[{"key":"GoTerm","value":"F:PH domain binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14739292"}]},{"database":"GO","id":"GO:0004252","properties":[{"key":"GoTerm","value":"F:serine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003697","properties":[{"key":"GoTerm","value":"F:single-stranded DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0003727","properties":[{"key":"GoTerm","value":"F:single-stranded RNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14739292"}]},{"database":"GO","id":"GO:0034599","properties":[{"key":"GoTerm","value":"P:cellular response to oxidative stress"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17420247"}]},{"database":"GO","id":"GO:0051131","properties":[{"key":"GoTerm","value":"P:chaperone-mediated protein complex assembly"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0035694","properties":[{"key":"GoTerm","value":"P:mitochondrial protein catabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37327776"}]},{"database":"GO","id":"GO:0007005","properties":[{"key":"GoTerm","value":"P:mitochondrion organization"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15683722"}]},{"database":"GO","id":"GO:0070407","properties":[{"key":"GoTerm","value":"P:oxidation-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12198491"}]},{"database":"GO","id":"GO:0006515","properties":[{"key":"GoTerm","value":"P:protein quality control for misfolded or incompletely synthesized proteins"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0051603","properties":[{"key":"GoTerm","value":"P:proteolysis involved in protein catabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17420247"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8248235"}]},{"database":"GO","id":"GO:0010044","properties":[{"key":"GoTerm","value":"P:response to aluminum ion"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009725","properties":[{"key":"GoTerm","value":"P:response to hormone"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001666","properties":[{"key":"GoTerm","value":"P:response to hypoxia"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"17418790"}]},{"database":"CDD","id":"cd19500","properties":[{"key":"EntryName","value":"RecA-like_Lon"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP03861","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"3.40.50.300:FF:000021","properties":[{"key":"EntryName","value":"Lon protease homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.8.60:FF:000043","properties":[{"key":"EntryName","value":"Lon protease homolog, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.5270:FF:000001","properties":[{"key":"EntryName","value":"Lon protease homolog, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.1480:FF:000002","properties":[{"key":"EntryName","value":"Lon protease homolog, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.130.40:FF:000004","properties":[{"key":"EntryName","value":"Lon protease homolog, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.230.10:FF:000015","properties":[{"key":"EntryName","value":"Lon protease homolog, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.8.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.5270","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1480","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.230.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.130.40","properties":[{"key":"EntryName","value":"LON domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_03120","properties":[{"key":"EntryName","value":"lonm_euk"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR003959","properties":[{"key":"EntryName","value":"ATPase_AAA_core"}]},{"database":"InterPro","id":"IPR004815","properties":[{"key":"EntryName","value":"Lon_bac/euk-typ"}]},{"database":"InterPro","id":"IPR054594","properties":[{"key":"EntryName","value":"Lon_lid"}]},{"database":"InterPro","id":"IPR008269","properties":[{"key":"EntryName","value":"Lon_proteolytic"}]},{"database":"InterPro","id":"IPR027065","properties":[{"key":"EntryName","value":"Lon_Prtase"}]},{"database":"InterPro","id":"IPR003111","properties":[{"key":"EntryName","value":"Lon_prtase_N"}]},{"database":"InterPro","id":"IPR046336","properties":[{"key":"EntryName","value":"Lon_prtase_N_sf"}]},{"database":"InterPro","id":"IPR027503","properties":[{"key":"EntryName","value":"Lonm_euk"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR008268","properties":[{"key":"EntryName","value":"Peptidase_S16_AS"}]},{"database":"InterPro","id":"IPR015947","properties":[{"key":"EntryName","value":"PUA-like_sf"}]},{"database":"InterPro","id":"IPR020568","properties":[{"key":"EntryName","value":"Ribosomal_Su5_D2-typ_SF"}]},{"database":"InterPro","id":"IPR014721","properties":[{"key":"EntryName","value":"Ribsml_uS5_D2-typ_fold_subgr"}]},{"database":"NCBIfam","id":"TIGR00763","properties":[{"key":"EntryName","value":"lon"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43718","properties":[{"key":"EntryName","value":"LON PROTEASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43718:SF2","properties":[{"key":"EntryName","value":"LON PROTEASE HOMOLOG, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00004","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05362","properties":[{"key":"EntryName","value":"Lon_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22667","properties":[{"key":"EntryName","value":"Lon_lid"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02190","properties":[{"key":"EntryName","value":"LON_substr_bdg"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00830","properties":[{"key":"EntryName","value":"ENDOLAPTASE"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00464","properties":[{"key":"EntryName","value":"LON"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF88697","properties":[{"key":"EntryName","value":"PUA domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54211","properties":[{"key":"EntryName","value":"Ribosomal protein S5 domain 2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51787","properties":[{"key":"EntryName","value":"LON_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51786","properties":[{"key":"EntryName","value":"LON_PROTEOLYTIC"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01046","properties":[{"key":"EntryName","value":"LON_SER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASPPWALWGRGPAIGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTAMGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFARAFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSLTGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPDEQAEALAVER","length":959,"molWeight":106489,"crc64":"B5E03D9C27C220FF","md5":"23BBC933C5C6A85B52600D3C16957113"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"COFACTOR":1,"ACTIVITY REGULATION":1,"SUBUNIT":1,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"DOMAIN":3,"PTM":1,"DISEASE":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Transit peptide":1,"Chain":1,"Domain":2,"Region":2,"Compositional bias":3,"Active site":2,"Binding site":28,"Modified residue":2,"Alternative sequence":2,"Natural variant":15,"Mutagenesis":19,"Sequence conflict":9,"Helix":43,"Beta strand":30,"Turn":4},"uniParcId":"UPI000012E7EF"}}