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Later in infection, F protein expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. F protein seems to trigger p53-dependent apoptosis"}],"commentType":"FUNCTION","molecule":"Fusion glycoprotein F2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P03420"}],"value":"Homotrimer. Heterodimer with fusion protein F2; disulfide-linked. Interacts with host NCL; this interaction plays a role in viral entry into the host cell. As a heterodimer with F2, interacts with host heparan sulfate. As a heterodimer with F2, interacts with host IGF1R; this interaction activates PRKCZ/PKCzeta that recruits NCL/nucleolin from the host nucleus to the plasma membrane. Part of a complex composed of F1, F2 and G glycoproteins. 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