{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P06733","secondaryAccessions":["B2RD59","P22712","Q16704","Q4TUS4","Q53FT9","Q53HR3","Q658M5","Q6GMP2","Q71V37","Q7Z3V6","Q8WU71","Q96GV1","Q9BT62","Q9UCH6","Q9UM55"],"uniProtkbId":"ENOA_HUMAN","entryAudit":{"firstPublicDate":"1988-01-01","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2007-01-23","entryVersion":271,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2373081"}],"value":"Alpha-enolase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1369209"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29775581"}],"value":"4.2.1.11"}]},"alternativeNames":[{"fullName":{"value":"2-phospho-D-glycerate hydro-lyase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2005901"}],"value":"C-myc promoter-binding protein"}},{"fullName":{"value":"Enolase 1"}},{"fullName":{"value":"MBP-1"}},{"fullName":{"value":"MPB-1"}},{"fullName":{"value":"Non-neural enolase"},"shortNames":[{"value":"NNE"}]},{"fullName":{"value":"Phosphopyruvate hydratase"}},{"fullName":{"value":"Plasminogen-binding protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:3350"}],"value":"ENO1"},"synonyms":[{"value":"ENO1L1"},{"value":"MBPB1"},{"value":"MPB1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10802057"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12666133"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1369209"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2005901"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29775581"}],"value":"Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis (PubMed:1369209, PubMed:29775581). 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Isoform MBP-1 interacts with TRAPPC2B (PubMed:11134351). Interacts with ENO4 and PGAM2 (By similarity). 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