{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P04406","secondaryAccessions":["E7EUT4","P00354","Q53X65"],"uniProtkbId":"G3P_HUMAN","entryAudit":{"firstPublicDate":"1986-07-21","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2007-01-23","entryVersion":280,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"6096136"}],"value":"Glyceraldehyde-3-phosphate dehydrogenase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2987855"}],"value":"GAPDH"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3170585"}],"value":"1.2.1.12"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Peptidyl-cysteine S-nitrosylase GAPDH"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04797"}],"value":"2.6.99.-"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2987855"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:4141"}],"value":"GAPDH"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"6096136"}],"value":"GAPD"}],"orfNames":[{"value":"CDABP0047"},{"value":"OK/SW-cl.12"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04797"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11724794"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23071094"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23332158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27387501"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3170585"}],"value":"Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis (PubMed:11724794, PubMed:3170585). Also shows nitrosylase activity, thereby playing a role in nuclear functions (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10300"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57604"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:59776"}],"ecNumber":"1.2.1.12","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10009"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3170585"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:10301"},"evidences":[{"evidenceCode":"ECO:0000305"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:10302"},"evidences":[{"evidenceCode":"ECO:0000305"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-nitroso-L-cysteinyl-[GAPDH] + L-cysteinyl-[protein] = L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:66684"},{"database":"Rhea","id":"RHEA-COMP:10131"},{"database":"Rhea","id":"RHEA-COMP:17089"},{"database":"Rhea","id":"RHEA-COMP:17090"},{"database":"Rhea","id":"RHEA-COMP:17091"},{"database":"ChEBI","id":"CHEBI:29950"},{"database":"ChEBI","id":"CHEBI:149494"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04797"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:66685"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04797"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04797"}],"value":"Glyceraldehyde-3-phosphate dehydrogenase activity is inhibited by fumarate, via the formation of S-(2-succinyl)cysteine residues"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"value":"Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04797"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10096"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11724794"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15479637"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15628863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16239728"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16501887"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16510976"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19001379"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20644585"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22771119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23332158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27387501"}],"value":"Homotetramer (PubMed:16239728, PubMed:16510976). Interacts with TPPP; the interaction is direct (By similarity). Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation (By similarity). Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation (By similarity). Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules (By similarity). Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS1 (PubMed:11724794, PubMed:15628863, PubMed:16501887, PubMed:20644585). Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:22771119). Component of the GAIT complex (PubMed:15479637). Interacts with FKBP6; leading to inhibit GAPDH catalytic activity (PubMed:19001379). Interacts with TRAF2, promoting TRAF2 ubiquitination (PubMed:23332158). Interacts with TRAF3, promoting TRAF3 ubiquitination (PubMed:27387501)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"Q6UY14-3","geneName":"ADAMTSL4","intActId":"EBI-10173507"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"Q9UIJ7","geneName":"AK3","intActId":"EBI-3916527"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"Q9UQM7","geneName":"CAMK2A","intActId":"EBI-1383687"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"Q14194","geneName":"CRMP1","intActId":"EBI-473101"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"P35222","geneName":"CTNNB1","intActId":"EBI-491549"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"Q9BPW9-4","geneName":"DHRS9","intActId":"EBI-19157435"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"P00533","geneName":"EGFR","intActId":"EBI-297353"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"O00471","geneName":"EXOC5","intActId":"EBI-949824"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"O75344","geneName":"FKBP6","intActId":"EBI-744771"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"P06241","geneName":"FYN","intActId":"EBI-515315"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"P04406","geneName":"GAPDH","intActId":"EBI-354056"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"O14556","geneName":"GAPDHS","intActId":"EBI-1057431"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"Q8NEA9","geneName":"GMCL2","intActId":"EBI-745707"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"Q92993-2","geneName":"KAT5","intActId":"EBI-20795332"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"P42695","geneName":"NCAPD3","intActId":"EBI-722805"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"P35228","geneName":"NOS2","intActId":"EBI-6662224"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"P12004","geneName":"PCNA","intActId":"EBI-358311"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"P00558","geneName":"PGK1","intActId":"EBI-709599"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"P48147","geneName":"PREP","intActId":"EBI-1049962"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"P17612","geneName":"PRKACA","intActId":"EBI-476586"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04406","intActId":"EBI-354056"},"interactantTwo":{"uniProtKBAccession":"Q8WUY3","geneName":"PRUNE2","intActId":"EBI-743880"},"numberOfExperiments":3,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Postnuclear and Perinuclear regions (PubMed:12829261)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12829261"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04797"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12829261"}],"value":"Cytoplasm, perinuclear region","id":"SL-0198"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12829261"}],"value":"Membrane","id":"SL-0162"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04797"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P04406-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P04406-2"],"sequenceIds":["VSP_047289"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25417112"}],"value":"The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04797"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22771119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25417112"}],"value":"S-nitrosylation of Cys-152 leads to interaction with SIAH1, followed by translocation to the nucleus (By similarity). S-nitrosylation of Cys-247 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity (PubMed:22771119, PubMed:25417112)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16815975"}],"value":"ISGylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P16858"}],"value":"Sulfhydration at Cys-152 increases catalytic activity"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25086035"}],"value":"Oxidative stress can promote the formation of high molecular weight disulfide-linked GAPDH aggregates, through a process called nucleocytoplasmic coagulation. Such aggregates can be observed in vivo in the affected tissues of patients with Alzheimer disease or alcoholic liver cirrhosis, or in cell cultures during necrosis. Oxidation at Met-46 may play a pivotal role in the formation of these insoluble structures. This modification has been detected in vitro following treatment with free radical donor (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide. It has been proposed to destabilize nearby residues, increasing the likelihood of secondary oxidative damages, including oxidation of Tyr-45 and Met-105. This cascade of oxidations may augment GAPDH misfolding, leading to intermolecular disulfide cross-linking and aggregation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04797"}],"value":"Succination of Cys-152 and Cys-247 by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits glyceraldehyde-3-phosphate dehydrogenase activity. Fumarate concentration as well as succination of cysteine residues in GAPDH is significantly increased in muscle of diabetic mammals. It was proposed that the S-(2-succinyl)cysteine chemical modification may be a useful biomarker of mitochondrial and oxidative stress in diabetes and that succination of GAPDH and other thiol proteins by fumarate may contribute to the metabolic changes underlying the development of diabetes complications"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23332158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27387501"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28522607"}],"value":"(Microbial infection) Glycosylated by C.rodentium protein NleB, enteropathogenic E.coli protein NleB1 and S.typhimurium protein Ssek1: arginine GlcNAcylation prevents the interaction with TRAF2 and TRAF3 (PubMed:23332158, PubMed:27387501, PubMed:28522607). This leads to reduced ubiquitination of TRAF2 and TRAF3, and subsequent inhibition of NF-kappa-B signaling and type I interferon production, respectively (PubMed:23332158, PubMed:27387501)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the glyceraldehyde-3-phosphate dehydrogenase family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Glyceraldehyde_3-phosphate_dehydrogenase","ftp":false,"note":"Glyceraldehyde 3-phosphate dehydrogenase entry"}],"features":[{"type":"Initiator 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