{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O75762","secondaryAccessions":["A6NIN6"],"uniProtkbId":"TRPA1_HUMAN","entryAudit":{"firstPublicDate":"2004-12-21","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2010-11-30","entryVersion":190,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:497"}],"value":"Transient receptor potential cation channel subfamily A member 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:497"}],"value":"Ankyrin-like with transmembrane domains protein 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10066796"}],"value":"Transformation-sensitive protein p120"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10066796"}],"value":"p120"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25855297"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"31447178"}],"value":"Wasabi receptor"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:497"}],"value":"TRPA1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:497"}],"value":"ANKTM1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BLA8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17164327"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17259981"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19202543"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20547126"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21195050"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23199233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25389312"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27241698"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30878828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33152265"}],"value":"Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21195050"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33152265"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Mg(2+)(in) = Mg(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29827"},{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21195050"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33152265"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Na(+)(in) = Na(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34963"},{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21195050"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"K(+)(in) = K(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29463"},{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21195050"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Zn(2+)(in) = Zn(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29351"},{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19202543"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6RI86"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17164327"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17259981"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17567811"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19202543"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20547126"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21402443"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25389312"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25855297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27241698"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30878828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31447178"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"}],"value":"Electrophilic ligands activate the channel by covalent modification of intracellular cysteines; Cys-621 plays a key role in covalent binding of electrophiles (PubMed:25389312, PubMed:27241698, PubMed:31866091, PubMed:32641835). Extracellular Ca(2+) both potentiates and inactivates TRPA1; a rapid potentiation follows by slow desensitization (By similarity). Activated by increase in intracellular Ca(2+) concentration (PubMed:17259981). Inhibited by the potent blocker of TRPV channels ruthenium red, A-967079, AP-18, HC-030031, and aryl sulfonamide derivative (S)-N-(4-chlorobenzyl)-1-((4-fluorophenyl)sulfonyl)pyrrolidine-2-carboxamide (ASD) (PubMed:17567811, PubMed:20547126, PubMed:21402443, PubMed:21873995, PubMed:30878828). Activated by benzyl isothiocyanate (BITC), iodoacetamide, sulfhydryl reactive agent MTSEA, N-methyl maleimide (NMM), N-ethylmaleimide (NEM), and 2-aminoethyldiphenylborinate (2-APB) (PubMed:17164327, PubMed:17567811, PubMed:21873995, PubMed:25855297, PubMed:27241698). Also activated by hyperoxia (PubMed:21873995). Acivated by intracellular Zn(2+) (PubMed:19202543). TRPA1 activation may critically depend on the presence of small intracellular compounds such as polyphosphates (PubMed:17567811)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BLA8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25389312"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25855297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31447178"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"}],"value":"Homotetramer (PubMed:25389312, PubMed:25855297, PubMed:31866091, PubMed:32641835). Interacts with TMEM100 (By similarity). Interacts with EGLN1 (By similarity). Interacts with the scorpion wasabi receptor toxin at the same site that electrophiles but in a non-covalent manner (PubMed:31447178)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O75762","intActId":"EBI-11722999"},"interactantTwo":{"uniProtKBAccession":"O75762","geneName":"TRPA1","intActId":"EBI-11722999"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20547126"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25389312"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25855297"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10066796"}],"value":"Expressed in embryos at 12 weeks of age"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}],"value":"C-terminal helices from the four subunits associate to form atypical coiled coil structure; this region is probably involved in binding the inositol polyphosphates that are required for optimal channel activity (in vitro)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25855297"}],"value":"The ANK repeat domain consists of a convex stem structure formed by five ANK repeats and 11 additional ANK repeats that form a crescent-shaped structure that surrounds the protein core"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25389312"}],"value":"TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the N-terminal cytoplasmic domain"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"}],"value":"Hydroxylation is required for TRPA1 activity inhibition in normoxia. In hypoxia, the decrease in oxygen concentration diminishes the activity of the hydroxylase EGLN1, thus relieving TRPA1 from inhibition and ultimately leading to channel activation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"}],"value":"Oxidation of Cys-633 and Cys-856 in hyperoxia may override the hydroxylase EGLN1-mediated inhibition, causing TRPA1 activation"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Episodic pain syndrome, familial, 1","diseaseAccession":"DI-03683","acronym":"FEPS1","description":"An autosomal dominant neurologic disorder characterized by onset in infancy of episodic debilitating upper body pain triggered by fasting, cold, and physical stress. The period of intense pain is accompanied by breathing difficulties, tachycardia, sweating, generalized pallor, peribuccal cyanosis, and stiffness of the abdominal wall. Affected individuals do not manifest altered pain sensitivity outside the episodes.","diseaseCrossReference":{"database":"MIM","id":"615040"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20547126"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the transient receptor (TC 1.A.4) family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Protein Spotlight","resourceUrl":"https://www.proteinspotlight.org/back_issues/082","ftp":false,"note":"The power behind pain - Issue 82 of May 2007"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1119,"modifier":"EXACT"}},"description":"Transient receptor potential cation channel subfamily A member 1","featureId":"PRO_0000215369"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":718,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":719,"modifier":"EXACT"},"end":{"value":739,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6PQO"}]},{"type":"Topological domain","location":{"start":{"value":740,"modifier":"EXACT"},"end":{"value":767,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":768,"modifier":"EXACT"},"end":{"value":793,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6PQO"}]},{"type":"Topological domain","location":{"start":{"value":794,"modifier":"EXACT"},"end":{"value":798,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":799,"modifier":"EXACT"},"end":{"value":823,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6PQO"}]},{"type":"Topological domain","location":{"start":{"value":824,"modifier":"EXACT"},"end":{"value":829,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":830,"modifier":"EXACT"},"end":{"value":850,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6PQO"}]},{"type":"Topological domain","location":{"start":{"value":851,"modifier":"EXACT"},"end":{"value":862,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":863,"modifier":"EXACT"},"end":{"value":892,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6PQO"}]},{"type":"Topological domain","location":{"start":{"value":893,"modifier":"EXACT"},"end":{"value":901,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Intramembrane","location":{"start":{"value":902,"modifier":"EXACT"},"end":{"value":922,"modifier":"EXACT"}},"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6PQO"}]},{"type":"Topological domain","location":{"start":{"value":923,"modifier":"EXACT"},"end":{"value":933,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":934,"modifier":"EXACT"},"end":{"value":960,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6PQO"}]},{"type":"Topological domain","location":{"start":{"value":961,"modifier":"EXACT"},"end":{"value":1119,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Repeat","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"ANK 1","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"ANK 2","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"ANK 3","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"ANK 4","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"ANK 5","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"ANK 6","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"ANK 7","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"ANK 8","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"ANK 9","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"ANK 10","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"ANK 11","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":474,"modifier":"EXACT"}},"description":"ANK 12","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":481,"modifier":"EXACT"},"end":{"value":510,"modifier":"EXACT"}},"description":"ANK 13","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":513,"modifier":"EXACT"},"end":{"value":542,"modifier":"EXACT"}},"description":"ANK 14","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":547,"modifier":"EXACT"},"end":{"value":576,"modifier":"EXACT"}},"description":"ANK 15","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Repeat","location":{"start":{"value":579,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"ANK 16","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Coiled coil","location":{"start":{"value":1042,"modifier":"EXACT"},"end":{"value":1071,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}]},{"type":"Binding site","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"covalent","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16731"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BLA8"}],"ligand":{"name":"(E)-cinnamaldehyde","id":"ChEBI:CHEBI:16731","note":"agonist"}},{"type":"Binding site","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"covalent","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16731"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BLA8"}],"ligand":{"name":"(E)-cinnamaldehyde","id":"ChEBI:CHEBI:16731","note":"agonist"}},{"type":"Binding site","location":{"start":{"value":621,"modifier":"EXACT"},"end":{"value":621,"modifier":"EXACT"}},"description":"covalent; Cys highly reactive","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16731"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BLA8"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17164327"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27241698"}],"ligand":{"name":"(E)-cinnamaldehyde","id":"ChEBI:CHEBI:16731","note":"agonist"}},{"type":"Binding site","location":{"start":{"value":641,"modifier":"EXACT"},"end":{"value":641,"modifier":"EXACT"}},"description":"covalent","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16731"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17164327"}],"ligand":{"name":"(E)-cinnamaldehyde","id":"ChEBI:CHEBI:16731","note":"agonist"}},{"type":"Binding site","location":{"start":{"value":665,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"covalent","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16731"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17164327"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27241698"}],"ligand":{"name":"(E)-cinnamaldehyde","id":"ChEBI:CHEBI:16731","note":"agonist"}},{"type":"Binding site","location":{"start":{"value":710,"modifier":"EXACT"},"end":{"value":710,"modifier":"EXACT"}},"description":"covalent","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16731"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17164327"}],"ligand":{"name":"(E)-cinnamaldehyde","id":"ChEBI:CHEBI:16731","note":"agonist"}},{"type":"Binding site","location":{"start":{"value":788,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6V9V"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":791,"modifier":"EXACT"},"end":{"value":791,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6V9V"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":805,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6V9V"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":808,"modifier":"EXACT"},"end":{"value":808,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6V9V"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":1046,"modifier":"EXACT"},"end":{"value":1052,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57880"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25855297"}],"ligand":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)","id":"ChEBI:CHEBI:57880"}},{"type":"Site","location":{"start":{"value":620,"modifier":"EXACT"},"end":{"value":620,"modifier":"EXACT"}},"description":"Required for C-621 reactivity","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27241698"}]},{"type":"Site","location":{"start":{"value":621,"modifier":"EXACT"},"end":{"value":621,"modifier":"EXACT"}},"description":"Essential for electrophile activation. Sensor for electrophilic agents","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"}]},{"type":"Site","location":{"start":{"value":622,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"Key residue for activation by the scorpion wasabi receptor toxin","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31447178"}]},{"type":"Site","location":{"start":{"value":634,"modifier":"EXACT"},"end":{"value":634,"modifier":"EXACT"}},"description":"Important residue for activation by the scorpion wasabi receptor toxin","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31447178"}]},{"type":"Site","location":{"start":{"value":646,"modifier":"EXACT"},"end":{"value":646,"modifier":"EXACT"}},"description":"Important residue for activation by the scorpion wasabi receptor toxin","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31447178"}]},{"type":"Site","location":{"start":{"value":665,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"Important for electrophile activation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"}]},{"type":"Site","location":{"start":{"value":915,"modifier":"EXACT"},"end":{"value":915,"modifier":"EXACT"}},"description":"Crucial for calcium permeation","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6RI86"}]},{"type":"Modified residue","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"4-hydroxyproline; by EGLN1; transient; in normoxia and hyperoxia","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"}]},{"type":"Modified residue","location":{"start":{"value":633,"modifier":"EXACT"},"end":{"value":633,"modifier":"EXACT"}},"description":"Cysteine sulfenic acid (-SOH); transient; in hyperoxia","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21873995"}]},{"type":"Modified residue","location":{"start":{"value":856,"modifier":"EXACT"},"end":{"value":856,"modifier":"EXACT"}},"description":"Cysteine sulfenic acid (-SOH); transient; in hyperoxia","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21873995"}]},{"type":"Glycosylation","location":{"start":{"value":747,"modifier":"EXACT"},"end":{"value":747,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":753,"modifier":"EXACT"},"end":{"value":753,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"Alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BLA8"}]},{"type":"Disulfide bond","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"Alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BLA8"}]},{"type":"Disulfide bond","location":{"start":{"value":608,"modifier":"EXACT"},"end":{"value":621,"modifier":"EXACT"}},"description":"Alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BLA8"}]},{"type":"Disulfide bond","location":{"start":{"value":621,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"Alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BLA8"}]},{"type":"Disulfide bond","location":{"start":{"value":633,"modifier":"EXACT"},"end":{"value":856,"modifier":"EXACT"}},"description":"Alternate; transient; in hyperoxia; unknown whether inter- or intrachain","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21873995"}]},{"type":"Natural variant","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":3,"modifier":"EXACT"}},"description":"in dbSNP:rs13268757","featureCrossReferences":[{"database":"dbSNP","id":"rs13268757"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10066796"}],"featureId":"VAR_020660","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"in dbSNP:rs16937976","featureCrossReferences":[{"database":"dbSNP","id":"rs16937976"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10066796"}],"featureId":"VAR_047471","alternativeSequence":{"originalSequence":"R","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"in dbSNP:rs920829","featureCrossReferences":[{"database":"dbSNP","id":"rs920829"}],"featureId":"VAR_020661","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"in dbSNP:rs7819749","featureCrossReferences":[{"database":"dbSNP","id":"rs7819749"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10066796"}],"featureId":"VAR_020662","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":855,"modifier":"EXACT"},"end":{"value":855,"modifier":"EXACT"}},"description":"in FEPS1; 5-fold increase in inward current when stimulated by the agonist cinnamaldehyde compared to wild-type at normal neuronal resting potential; consistent with a gain of function mutation; dbSNP:rs398123010","featureCrossReferences":[{"database":"dbSNP","id":"rs398123010"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20547126"}],"featureId":"VAR_069737","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":1018,"modifier":"EXACT"},"end":{"value":1018,"modifier":"EXACT"}},"description":"in dbSNP:rs959976","featureCrossReferences":[{"database":"dbSNP","id":"rs959976"}],"featureId":"VAR_020663","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Decrease in activation by hyperoxia and diallyl disulfide.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"Decrease in activation by hyperoxia and diallyl disulfide.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Loss of answer to hypoxia and hydroxylase inhibitor DMOG, but not to AITC and hyperoxia.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":620,"modifier":"EXACT"},"end":{"value":620,"modifier":"EXACT"}},"description":"Important decrease in electrophile-evoked response.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27241698"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":621,"modifier":"EXACT"},"end":{"value":621,"modifier":"EXACT"}},"description":"Do not exhibit detectable current upon electrophile stimulation. No change in answer to hyperoxia and diallyl disulfide. Do not exhibit detectable currents upon stimulation with agonist JT010.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27241698"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30878828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A","S"]}},{"type":"Mutagenesis","location":{"start":{"value":622,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"Loss of activation by the scorpion wasabi receptor toxin.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31447178"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":633,"modifier":"EXACT"},"end":{"value":633,"modifier":"EXACT"}},"description":"Decrease in activation by hyperoxia and diallyl disulfide. Important decrease in activation by hyperoxia and diallyl disulfide; when associated with S-856.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":634,"modifier":"EXACT"},"end":{"value":634,"modifier":"EXACT"}},"description":"Loss of activation by the scorpion wasabi receptor toxin.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31447178"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":641,"modifier":"EXACT"},"end":{"value":641,"modifier":"EXACT"}},"description":"Decrease in electrophile-evoked and hyperoxia response.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A","S"]}},{"type":"Mutagenesis","location":{"start":{"value":641,"modifier":"EXACT"},"end":{"value":641,"modifier":"EXACT"}},"description":"Does not affect activation by electrophiles.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":646,"modifier":"EXACT"},"end":{"value":646,"modifier":"EXACT"}},"description":"Loss of activation by the scorpion wasabi receptor toxin.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31447178"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Mutagenesis","location":{"start":{"value":665,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"Decrease in electrophile-evoked and hyperoxia response. Does not affect covalent agonist BITC electrophile-evoked.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27241698"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31866091"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A","L","S"]}},{"type":"Mutagenesis","location":{"start":{"value":788,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"Lacks calcium-mediated potentiation but retains calcium-mediated desensitization. Lacks calcium-mediated potentiation and lacks calcium-mediated desensitization; when associated with S-191 and S-805.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":791,"modifier":"EXACT"},"end":{"value":791,"modifier":"EXACT"}},"description":"Lacks calcium-mediated potentiation and lacks desensitization; when associated with S-788 and S-805.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":805,"modifier":"EXACT"}},"description":"Lacks calcium-mediated potentiation and lacks desensitization; when associated with S-788 and S-791.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32641835"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":856,"modifier":"EXACT"},"end":{"value":856,"modifier":"EXACT"}},"description":"Decrease in activation by hyperoxia and diallyl disulfide. Important decrease in activation by hyperoxia and diallyl disulfide; when associated with S-633.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21873995"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":909,"modifier":"EXACT"},"end":{"value":909,"modifier":"EXACT"}},"description":"Loss of inhibition by A-967079, AP-18, and ASD. Increase in activation by cinnamaldehyde, AITC and acrolein.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25855297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30878828"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A","T"]}},{"type":"Mutagenesis","location":{"start":{"value":915,"modifier":"EXACT"},"end":{"value":915,"modifier":"EXACT"}},"description":"Abolishes zinc influx. Abolishes activation by extracellular but not by intracellular zinc.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19202543"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":944,"modifier":"EXACT"},"end":{"value":944,"modifier":"EXACT"}},"description":"Loss of inhibition by A-967079, AP-18, and ASD. Weak or no change in activation by cinnamaldehyde, AITC and acrolein.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30878828"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Helix","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6HC8"}]},{"type":"Helix","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":455,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Turn","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":477,"modifier":"EXACT"},"end":{"value":479,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JUP"}]},{"type":"Helix","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":504,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":512,"modifier":"EXACT"},"end":{"value":514,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9W"}]},{"type":"Helix","location":{"start":{"value":517,"modifier":"EXACT"},"end":{"value":522,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Turn","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":525,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":527,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Turn","location":{"start":{"value":534,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Beta strand","location":{"start":{"value":538,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":551,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":561,"modifier":"EXACT"},"end":{"value":569,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Beta strand","location":{"start":{"value":578,"modifier":"EXACT"},"end":{"value":580,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9X"}]},{"type":"Helix","location":{"start":{"value":583,"modifier":"EXACT"},"end":{"value":589,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":593,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Beta strand","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":605,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Beta strand","location":{"start":{"value":617,"modifier":"EXACT"},"end":{"value":619,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":622,"modifier":"EXACT"},"end":{"value":628,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":631,"modifier":"EXACT"},"end":{"value":641,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Beta strand","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":647,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OR0"}]},{"type":"Beta strand","location":{"start":{"value":650,"modifier":"EXACT"},"end":{"value":653,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6PQP"}]},{"type":"Beta strand","location":{"start":{"value":656,"modifier":"EXACT"},"end":{"value":659,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Beta strand","location":{"start":{"value":661,"modifier":"EXACT"},"end":{"value":663,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Turn","location":{"start":{"value":668,"modifier":"EXACT"},"end":{"value":670,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":673,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6PQP"}]},{"type":"Helix","location":{"start":{"value":684,"modifier":"EXACT"},"end":{"value":691,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":695,"modifier":"EXACT"},"end":{"value":698,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":701,"modifier":"EXACT"},"end":{"value":710,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":711,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":716,"modifier":"EXACT"},"end":{"value":739,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Beta strand","location":{"start":{"value":742,"modifier":"EXACT"},"end":{"value":744,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Beta strand","location":{"start":{"value":745,"modifier":"EXACT"},"end":{"value":747,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OR0"}]},{"type":"Beta strand","location":{"start":{"value":750,"modifier":"EXACT"},"end":{"value":753,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OR0"}]},{"type":"Beta strand","location":{"start":{"value":761,"modifier":"EXACT"},"end":{"value":763,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OR0"}]},{"type":"Helix","location":{"start":{"value":767,"modifier":"EXACT"},"end":{"value":794,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Beta strand","location":{"start":{"value":795,"modifier":"EXACT"},"end":{"value":799,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":804,"modifier":"EXACT"},"end":{"value":818,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":820,"modifier":"EXACT"},"end":{"value":822,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":828,"modifier":"EXACT"},"end":{"value":849,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Beta strand","location":{"start":{"value":851,"modifier":"EXACT"},"end":{"value":856,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":857,"modifier":"EXACT"},"end":{"value":871,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":874,"modifier":"EXACT"},"end":{"value":891,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Turn","location":{"start":{"value":892,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Beta strand","location":{"start":{"value":898,"modifier":"EXACT"},"end":{"value":900,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":901,"modifier":"EXACT"},"end":{"value":910,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":911,"modifier":"EXACT"},"end":{"value":913,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":919,"modifier":"EXACT"},"end":{"value":923,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":924,"modifier":"EXACT"},"end":{"value":927,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":934,"modifier":"EXACT"},"end":{"value":945,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":946,"modifier":"EXACT"},"end":{"value":952,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":953,"modifier":"EXACT"},"end":{"value":969,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":971,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Helix","location":{"start":{"value":992,"modifier":"EXACT"},"end":{"value":998,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Beta strand","location":{"start":{"value":1001,"modifier":"EXACT"},"end":{"value":1005,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]},{"type":"Beta strand","location":{"start":{"value":1007,"modifier":"EXACT"},"end":{"value":1009,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6PQQ"}]},{"type":"Helix","location":{"start":{"value":1016,"modifier":"EXACT"},"end":{"value":1024,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6PQQ"}]},{"type":"Helix","location":{"start":{"value":1041,"modifier":"EXACT"},"end":{"value":1070,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V9V"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-0107","category":"Molecular function","name":"Calcium channel"},{"id":"KW-0109","category":"Biological process","name":"Calcium transport"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0379","category":"PTM","name":"Hydroxylation"},{"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0558","category":"PTM","name":"Oxidation"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0716","category":"Biological process","name":"Sensory transduction"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"10066796","citationType":"journal article","authors":["Jaquemar D.","Schenker T.","Trueb B."],"citationCrossReferences":[{"database":"PubMed","id":"10066796"},{"database":"DOI","id":"10.1074/jbc.274.11.7325"}],"title":"An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"7325","lastPage":"7333","volume":"274"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","DEVELOPMENTAL STAGE","VARIANTS CYS-3; THR-58 AND ASN-186"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L. III","Engels R.","Gloeckner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.J.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"17164327","citationType":"journal article","authors":["Hinman A.","Chuang H.H.","Bautista D.M.","Julius D."],"citationCrossReferences":[{"database":"PubMed","id":"17164327"},{"database":"DOI","id":"10.1073/pnas.0609598103"}],"title":"TRP channel activation by reversible covalent modification.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"19564","lastPage":"19568","volume":"103"},"referencePositions":["FUNCTION","ACTIVITY REGULATION"]},{"referenceNumber":4,"citation":{"id":"17567811","citationType":"journal article","authors":["Kim D.","Cavanaugh E.J."],"citationCrossReferences":[{"database":"PubMed","id":"17567811"},{"database":"DOI","id":"10.1523/jneurosci.0623-07.2007"}],"title":"Requirement of a soluble intracellular factor for activation of transient receptor potential A1 by pungent chemicals: role of inorganic polyphosphates.","publicationDate":"2007","journal":"J. Neurosci.","firstPage":"6500","lastPage":"6509","volume":"27"},"referencePositions":["ACTIVITY REGULATION"]},{"referenceNumber":5,"citation":{"id":"17259981","citationType":"journal article","authors":["Zurborg S.","Yurgionas B.","Jira J.A.","Caspani O.","Heppenstall P.A."],"citationCrossReferences":[{"database":"PubMed","id":"17259981"},{"database":"DOI","id":"10.1038/nn1843"}],"title":"Direct activation of the ion channel TRPA1 by Ca2+.","publicationDate":"2007","journal":"Nat. Neurosci.","firstPage":"277","lastPage":"279","volume":"10"},"referencePositions":["FUNCTION","ACTIVITY REGULATION"]},{"referenceNumber":6,"citation":{"id":"21195050","citationType":"journal article","authors":["Bobkov Y.V.","Corey E.A.","Ache B.W."],"citationCrossReferences":[{"database":"PubMed","id":"21195050"},{"database":"DOI","id":"10.1016/j.bbamem.2010.12.024"}],"title":"The pore properties of human nociceptor channel TRPA1 evaluated in single channel recordings.","publicationDate":"2011","journal":"Biochim. Biophys. Acta","firstPage":"1120","lastPage":"1128","volume":"1808"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY"]},{"referenceNumber":7,"citation":{"id":"19202543","citationType":"journal article","authors":["Hu H.","Bandell M.","Petrus M.J.","Zhu M.X.","Patapoutian A."],"citationCrossReferences":[{"database":"PubMed","id":"19202543"},{"database":"DOI","id":"10.1038/nchembio.146"}],"title":"Zinc activates damage-sensing TRPA1 ion channels.","publicationDate":"2009","journal":"Nat. Chem. Biol.","firstPage":"183","lastPage":"190","volume":"5"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","ACTIVITY REGULATION","MUTAGENESIS OF ASP-915"]},{"referenceNumber":8,"citation":{"id":"21873995","citationType":"journal article","authors":["Takahashi N.","Kuwaki T.","Kiyonaka S.","Numata T.","Kozai D.","Mizuno Y.","Yamamoto S.","Naito S.","Knevels E.","Carmeliet P.","Oga T.","Kaneko S.","Suga S.","Nokami T.","Yoshida J.","Mori Y."],"citationCrossReferences":[{"database":"PubMed","id":"21873995"},{"database":"DOI","id":"10.1038/nchembio.640"}],"title":"TRPA1 underlies a sensing mechanism for O2.","publicationDate":"2011","journal":"Nat. Chem. Biol.","firstPage":"701","lastPage":"711","volume":"7"},"referencePositions":["FUNCTION","ACTIVITY REGULATION","HYDROXYLATION AT PRO-394","OXIDATION AT CYS-633 AND CYS-856","MUTAGENESIS OF CYS-173; CYS-192; PRO-394; CYS-621; CYS-633; CYS-641; CYS-665 AND CYS-856","SUBCELLULAR LOCATION"]},{"referenceNumber":9,"citation":{"id":"21402443","citationType":"journal article","authors":["Chen J.","Joshi S.K.","DiDomenico S.","Perner R.J.","Mikusa J.P.","Gauvin D.M.","Segreti J.A.","Han P.","Zhang X.F.","Niforatos W.","Bianchi B.R.","Baker S.J.","Zhong C.","Simler G.H.","McDonald H.A.","Schmidt R.G.","McGaraughty S.P.","Chu K.L.","Faltynek C.R.","Kort M.E.","Reilly R.M.","Kym P.R."],"citationCrossReferences":[{"database":"PubMed","id":"21402443"},{"database":"DOI","id":"10.1016/j.pain.2011.01.049"}],"title":"Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.","publicationDate":"2011","journal":"Pain","firstPage":"1165","lastPage":"1172","volume":"152"},"referencePositions":["ACTIVITY REGULATION"]},{"referenceNumber":10,"citation":{"id":"23199233","citationType":"journal article","authors":["Buday T.","Brozmanova M.","Biringerova Z.","Gavliakova S.","Poliacek I.","Calkovsky V.","Shetthalli M.V.","Plevkova J."],"citationCrossReferences":[{"database":"PubMed","id":"23199233"},{"database":"DOI","id":"10.1186/1745-9974-8-11"}],"title":"Modulation of cough response by sensory inputs from the nose - role of trigeminal TRPA1 versus TRPM8 channels.","publicationDate":"2012","journal":"Cough","firstPage":"11","lastPage":"11","volume":"8"},"referencePositions":["FUNCTION"]},{"referenceNumber":11,"citation":{"id":"25389312","citationType":"journal article","authors":["Moparthi L.","Survery S.","Kreir M.","Simonsen C.","Kjellbom P.","Hoegestaett E.D.","Johanson U.","Zygmunt P.M."],"citationCrossReferences":[{"database":"PubMed","id":"25389312"},{"database":"DOI","id":"10.1073/pnas.1412689111"}],"title":"Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain.","publicationDate":"2014","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"16901","lastPage":"16906","volume":"111"},"referencePositions":["FUNCTION","SUBUNIT","SUBCELLULAR LOCATION","ACTIVITY REGULATION"]},{"referenceNumber":12,"citation":{"id":"27241698","citationType":"journal article","authors":["Bahia P.K.","Parks T.A.","Stanford K.R.","Mitchell D.A.","Varma S.","Stevens S.M. Jr.","Taylor-Clark T.E."],"citationCrossReferences":[{"database":"PubMed","id":"27241698"},{"database":"DOI","id":"10.1085/jgp.201611581"}],"title":"The exceptionally high reactivity of Cys 621 is critical for electrophilic activation of the sensory nerve ion channel TRPA1.","publicationDate":"2016","journal":"J. Gen. Physiol.","firstPage":"451","lastPage":"465","volume":"147"},"referencePositions":["FUNCTION","ACTIVITY REGULATION","MUTAGENESIS OF LYS-620; CYS-621 AND CYS-665"]},{"referenceNumber":13,"citation":{"id":"31447178","citationType":"journal article","authors":["Lin King J.V.","Emrick J.J.","Kelly M.J.S.","Herzig V.","King G.F.","Medzihradszky K.F.","Julius D."],"citationCrossReferences":[{"database":"PubMed","id":"31447178"},{"database":"DOI","id":"10.1016/j.cell.2019.07.014"}],"title":"A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and pain.","publicationDate":"2019","journal":"Cell","firstPage":"1362","lastPage":"1374","volume":"178"},"referencePositions":["MUTAGENESIS OF PRO-622; MET-634 AND THR-646","SUBUNIT"]},{"referenceNumber":14,"citation":{"id":"30878828","citationType":"journal article","authors":["Chandrabalan A.","McPhillie M.J.","Morice A.H.","Boa A.N.","Sadofsky L.R."],"citationCrossReferences":[{"database":"PubMed","id":"30878828"},{"database":"DOI","id":"10.1016/j.ejmech.2019.02.074"}],"title":"N-Cinnamoylanthranilates as human TRPA1 modulators: structure-activity relationships and channel binding sites.","publicationDate":"2019","journal":"Eur. J. Med. Chem.","firstPage":"141","lastPage":"156","volume":"170"},"referencePositions":["FUNCTION","ACTIVITY REGULATION","MUTAGENESIS OF CYS-621; PHE-909 AND PHE-944"]},{"referenceNumber":15,"citation":{"id":"25855297","citationType":"journal article","authors":["Paulsen C.E.","Armache J.P.","Gao Y.","Cheng Y.","Julius D."],"citationCrossReferences":[{"database":"PubMed","id":"25855297"},{"database":"DOI","id":"10.1038/nature14367"}],"title":"Structure of the TRPA1 ion channel suggests regulatory mechanisms.","publicationDate":"2015","journal":"Nature","firstPage":"511","lastPage":"517","volume":"520"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (4.24 ANGSTROMS) IN COMPLEXES WITH SYNTHETIC AGONISTS","ACTIVITY REGULATION","SUBUNIT","SUBCELLULAR LOCATION","DOMAIN","MUTAGENESIS OF PHE-909"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3J9P"}]},{"referenceNumber":16,"citation":{"id":"26200340","citationType":"journal article","authors":["Paulsen C.E.","Armache J.P.","Gao Y.","Cheng Y.","Julius D."],"citationCrossReferences":[{"database":"PubMed","id":"26200340"},{"database":"DOI","id":"10.1038/nature14871"}],"publicationDate":"2015","journal":"Nature","firstPage":"552","lastPage":"552","volume":"525"},"referencePositions":["ERRATUM OF PUBMED:25855297"]},{"referenceNumber":17,"citation":{"id":"32641835","citationType":"journal article","authors":["Zhao J.","Lin King J.V.","Paulsen C.E.","Cheng Y.","Julius D."],"citationCrossReferences":[{"database":"PubMed","id":"32641835"},{"database":"DOI","id":"10.1038/s41586-020-2480-9"}],"title":"Irritant-evoked activation and calcium modulation of the TRPA1 receptor.","publicationDate":"2020","journal":"Nature","firstPage":"141","lastPage":"145","volume":"585"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.60 ANGSTROMS) IN COMPLEX WITH CALCIUM AND AGONISTS","FUNCTION","SUBUNIT","MUTAGENESIS OF CYS-621; CYS-641; CYS-665; GLU-788; GLN-791 AND ASN-805"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6V9V"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6V9W"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6V9X"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6V9Y"}]},{"referenceNumber":18,"citation":{"id":"31866091","citationType":"journal article","authors":["Suo Y.","Wang Z.","Zubcevic L.","Hsu A.L.","He Q.","Borgnia M.J.","Ji R.R.","Lee S.Y."],"citationCrossReferences":[{"database":"PubMed","id":"31866091"},{"database":"DOI","id":"10.1016/j.neuron.2019.11.023"}],"title":"Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.","publicationDate":"2020","journal":"Neuron","firstPage":"882","lastPage":"894.e5","volume":"105"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.81 ANGSTROMS) OF 2-1119 IN COMPLEX WITH AGONIST","FUNCTION","SUBUNIT","MUTAGENESIS OF CYS-621 AND CYS-665"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6PQO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6PQP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6PQQ"}]},{"referenceNumber":19,"citation":{"id":"33152265","citationType":"journal article","authors":["Liu C.","Reese R.","Vu S.","Rouge L.","Shields S.D.","Kakiuchi-Kiyota S.","Chen H.","Johnson K.","Shi Y.P.","Chernov-Rogan T.","Greiner D.M.Z.","Kohli P.B.","Hackos D.","Brillantes B.","Tam C.","Li T.","Wang J.","Safina B.","Magnuson S.","Volgraf M.","Payandeh J.","Zheng J.","Rohou A.","Chen J."],"citationCrossReferences":[{"database":"PubMed","id":"33152265"},{"database":"DOI","id":"10.1016/j.neuron.2020.10.014"}],"title":"A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel.","publicationDate":"2021","journal":"Neuron","firstPage":"273","lastPage":"284.e4","volume":"109"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.00 ANGSTROMS) OF 448-1078 IN COMPLEX WITH AGONIST","FUNCTION","TRANSPORTER ACTIVITY"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6X2J"}]},{"referenceNumber":20,"citation":{"id":"20547126","citationType":"journal article","authors":["Kremeyer B.","Lopera F.","Cox J.J.","Momin A.","Rugiero F.","Marsh S.","Woods C.G.","Jones N.G.","Paterson K.J.","Fricker F.R.","Villegas A.","Acosta N.","Pineda-Trujillo N.G.","Ramirez J.D.","Zea J.","Burley M.W.","Bedoya G.","Bennett D.L.","Wood J.N.","Ruiz-Linares A."],"citationCrossReferences":[{"database":"PubMed","id":"20547126"},{"database":"DOI","id":"10.1016/j.neuron.2010.04.030"}],"title":"A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome.","publicationDate":"2010","journal":"Neuron","firstPage":"671","lastPage":"680","volume":"66"},"referencePositions":["VARIANT FEPS1 SER-855","CHARACTERIZATION OF VARIANT FEPS1 SER-855","FUNCTION","SUBCELLULAR LOCATION","ACTIVITY REGULATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Y10601","properties":[{"key":"ProteinId","value":"CAA71610.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC022867","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS34908.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_015628.2","properties":[{"key":"NucleotideSequenceId","value":"NM_007332.3"}]},{"database":"RefSeq","id":"XP_011515927.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011517625.3"}]},{"database":"PDB","id":"3J9P","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.24 A"},{"key":"Chains","value":"A/B/C/D=2-1119"}]},{"database":"PDB","id":"6HC8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"E=313-339"}]},{"database":"PDB","id":"6PQO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.88 A"},{"key":"Chains","value":"A/B/C/D=2-1119"}]},{"database":"PDB","id":"6PQP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.06 A"},{"key":"Chains","value":"A/B/C/D=2-1119"}]},{"database":"PDB","id":"6PQQ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.81 A"},{"key":"Chains","value":"A/B/C/D=2-1119"}]},{"database":"PDB","id":"6V9V","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/B/C/D=1-1119"}]},{"database":"PDB","id":"6V9W","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B/C/D=1-1119"}]},{"database":"PDB","id":"6V9X","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A/B/C/D=1-1119"}]},{"database":"PDB","id":"6V9Y","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"A/B/C/D=1-1119"}]},{"database":"PDB","id":"6WJ5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"A/B/C/D=448-1078"}]},{"database":"PDB","id":"6X2J","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B/C/D=448-1078"}]},{"database":"PDB","id":"7JUP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.05 A"},{"key":"Chains","value":"A/B/C/D=448-1078"}]},{"database":"PDB","id":"7OR0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.64 A"},{"key":"Chains","value":"A/B/C/D=1-1119"}]},{"database":"PDB","id":"7OR1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.64 A"},{"key":"Chains","value":"A/B/C/D=1-1119"}]},{"database":"PDB","id":"9M8N","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.81 A"},{"key":"Chains","value":"A/B/C/D=1-1119"}]},{"database":"PDB","id":"9M8S","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B/C/D=1-1119"}]},{"database":"PDB","id":"9MOE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B/D/E=2-1119"}]},{"database":"PDBsum","id":"3J9P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6HC8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PQO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PQP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PQQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V9V","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V9W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V9X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V9Y","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6WJ5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X2J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JUP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7OR0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7OR1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9M8N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9M8S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9MOE","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-13036","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-13037","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20449","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20450","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20451","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21127","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21128","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21129","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21130","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21131","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21688","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-22009","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-22490","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-48457","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-6267","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-6268","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-6269","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-63715","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-63720","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"114471","properties":[{"key":"Interactions","value":"8"}]},{"database":"CORUM","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-61520N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O75762","properties":[{"key":"Number of interactors","value":"572"}]},{"database":"IntAct","id":"O75762","properties":[{"key":"Interactions","value":"3"}]},{"database":"MINT","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-TRPA1","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000262209","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL6007","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB11345","properties":[{"key":"GenericName","value":"(S)-camphor"}]},{"database":"DrugBank","id":"DB11148","properties":[{"key":"GenericName","value":"Butamben"}]},{"database":"DrugBank","id":"DB01744","properties":[{"key":"GenericName","value":"Camphor"}]},{"database":"DrugBank","id":"DB09061","properties":[{"key":"GenericName","value":"Cannabidiol"}]},{"database":"DrugBank","id":"DB14050","properties":[{"key":"GenericName","value":"Cannabidivarin"}]},{"database":"DrugBank","id":"DB14184","properties":[{"key":"GenericName","value":"Cinnamaldehyde"}]},{"database":"DrugBank","id":"DB04381","properties":[{"key":"GenericName","value":"Crotonaldehyde"}]},{"database":"DrugBank","id":"DB13716","properties":[{"key":"GenericName","value":"Dibutylphthalate"}]},{"database":"DrugBank","id":"DB03843","properties":[{"key":"GenericName","value":"Formaldehyde"}]},{"database":"DrugBank","id":"DB19255","properties":[{"key":"GenericName","value":"Gingerol"}]},{"database":"DrugBank","id":"DB00825","properties":[{"key":"GenericName","value":"Levomenthol"}]},{"database":"DrugBank","id":"DB14009","properties":[{"key":"GenericName","value":"Medical Cannabis"}]},{"database":"DrugBank","id":"DB12765","properties":[{"key":"GenericName","value":"Methyl isocyanate"}]},{"database":"DrugBank","id":"DB09543","properties":[{"key":"GenericName","value":"Methyl salicylate"}]},{"database":"DrugBank","id":"DB14212","properties":[{"key":"GenericName","value":"Methylparaben"}]},{"database":"DrugBank","id":"DB14011","properties":[{"key":"GenericName","value":"Nabiximols"}]},{"database":"DrugBank","id":"DB03587","properties":[{"key":"GenericName","value":"Pyruvaldehyde"}]},{"database":"DrugBank","id":"DB11755","properties":[{"key":"GenericName","value":"Tetrahydrocannabivarin"}]},{"database":"DrugCentral","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"485","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.A.4.6.3","properties":[{"key":"FamilyName","value":"the transient receptor potential ca2+/cation channel (trp-cc) family"}]},{"database":"GlyCosmos","id":"O75762","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"O75762","properties":[{"key":"glycosylation","value":"2 sites"}]},{"database":"iPTMnet","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"TRPA1","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000262209","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"50181","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"12262","properties":[{"key":"antibodies","value":"306 antibodies from 32 providers"}]},{"database":"DNASU","id":"8989","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000262209.5","properties":[{"key":"ProteinId","value":"ENSP00000262209.4"},{"key":"GeneId","value":"ENSG00000104321.12"}]},{"database":"Ensembl","id":"ENST00000859810.1","properties":[{"key":"ProteinId","value":"ENSP00000529869.1"},{"key":"GeneId","value":"ENSG00000104321.12"}]},{"database":"GeneID","id":"8989","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:8989","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000262209.5","properties":[{"key":"ProteinId","value":"ENSP00000262209.4"},{"key":"RefSeqNucleotideId","value":"NM_007332.3"},{"key":"RefSeqProteinId","value":"NP_015628.2"}]},{"database":"UCSC","id":"uc003xza.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:497","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"8989","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"8989","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"TRPA1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:497","properties":[{"key":"GeneName","value":"TRPA1"}]},{"database":"HPA","id":"ENSG00000104321","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (intestine, stomach, urinary bladder)"}]},{"database":"MalaCards","id":"TRPA1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"604775","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"615040","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000104321","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"581271","properties":[{"key":"Disease","value":"Cramp-fasciculation syndrome"}]},{"database":"Orphanet","id":"391389","properties":[{"key":"Disease","value":"Familial episodic pain syndrome with predominantly upper body involvement"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000104321","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0510","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000156118","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HWATEKN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"1661883at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"O75762","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-3295583","properties":[{"key":"PathwayName","value":"TRP channels"}]},{"database":"SignaLink","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000104321","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"8989","properties":[{"key":"hits","value":"6 hits in 1151 CRISPR screens"}]},{"database":"EvolutionaryTrace","id":"O75762","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"8989","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"O75762","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:O75762","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"RNAct","id":"O75762","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000104321","properties":[{"key":"ExpressionPatterns","value":"Expressed in oocyte and 110 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"O75762","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016324","properties":[{"key":"GoTerm","value":"C:apical plasma membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20547126"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25855297"}]},{"database":"GO","id":"GO:0032421","properties":[{"key":"GoTerm","value":"C:stereocilium bundle"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005262","properties":[{"key":"GoTerm","value":"F:calcium channel activity"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0015267","properties":[{"key":"GoTerm","value":"F:channel activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10066796"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"25855297"}]},{"database":"GO","id":"GO:0015278","properties":[{"key":"GoTerm","value":"F:intracellularly gated calcium channel activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20547126"}]},{"database":"GO","id":"GO:1990760","properties":[{"key":"GoTerm","value":"F:osmolarity-sensing monoatomic cation channel activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097604","properties":[{"key":"GoTerm","value":"F:temperature-gated cation channel activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20547126"}]},{"database":"GO","id":"GO:0005245","properties":[{"key":"GoTerm","value":"F:voltage-gated calcium channel activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097553","properties":[{"key":"GoTerm","value":"P:calcium ion transmembrane import into cytosol"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0070588","properties":[{"key":"GoTerm","value":"P:calcium ion transmembrane transport"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20547126"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25855297"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"25605129"}]},{"database":"GO","id":"GO:0071313","properties":[{"key":"GoTerm","value":"P:cellular response to caffeine"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071244","properties":[{"key":"GoTerm","value":"P:cellular response to carbon dioxide"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0070417","properties":[{"key":"GoTerm","value":"P:cellular response to cold"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071240","properties":[{"key":"GoTerm","value":"P:cellular response to food"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"25605129"}]},{"database":"GO","id":"GO:0034605","properties":[{"key":"GoTerm","value":"P:cellular response to heat"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0070301","properties":[{"key":"GoTerm","value":"P:cellular response to hydrogen peroxide"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30990108"}]},{"database":"GO","id":"GO:0097237","properties":[{"key":"GoTerm","value":"P:cellular response to toxic substance"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0050968","properties":[{"key":"GoTerm","value":"P:detection of chemical stimulus involved in sensory perception of pain"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0050974","properties":[{"key":"GoTerm","value":"P:detection of mechanical stimulus involved in sensory perception"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006874","properties":[{"key":"GoTerm","value":"P:intracellular calcium ion homeostasis"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30990108"}]},{"database":"GO","id":"GO:0006811","properties":[{"key":"GoTerm","value":"P:monoatomic ion transport"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10066796"}]},{"database":"GO","id":"GO:0035774","properties":[{"key":"GoTerm","value":"P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1903793","properties":[{"key":"GoTerm","value":"P:positive regulation of monoatomic anion transport"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0051289","properties":[{"key":"GoTerm","value":"P:protein homotetramerization"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25855297"}]},{"database":"GO","id":"GO:1903522","properties":[{"key":"GoTerm","value":"P:regulation of blood circulation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0098908","properties":[{"key":"GoTerm","value":"P:regulation of neuronal action potential"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009409","properties":[{"key":"GoTerm","value":"P:response to cold"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20547126"}]},{"database":"GO","id":"GO:0019233","properties":[{"key":"GoTerm","value":"P:sensory perception of pain"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20547126"}]},{"database":"GO","id":"GO:0050955","properties":[{"key":"GoTerm","value":"P:thermoception"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0014832","properties":[{"key":"GoTerm","value":"P:urinary bladder smooth muscle contraction"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"FunFam","id":"1.25.40.20:FF:000186","properties":[{"key":"EntryName","value":"Transient receptor potential cation channel A1, isoform K"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.20:FF:000272","properties":[{"key":"EntryName","value":"Transient receptor potential cation channel subfamily A member 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.20:FF:000866","properties":[{"key":"EntryName","value":"Transient receptor potential cation channel subfamily A member 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"5"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR005821","properties":[{"key":"EntryName","value":"Ion_trans_dom"}]},{"database":"InterPro","id":"IPR052076","properties":[{"key":"EntryName","value":"TRP_cation_channel"}]},{"database":"PANTHER","id":"PTHR47143:SF1","properties":[{"key":"EntryName","value":"ION_TRANS DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47143","properties":[{"key":"EntryName","value":"TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00023","properties":[{"key":"EntryName","value":"Ank"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"4"}]},{"database":"Pfam","id":"PF13637","properties":[{"key":"EntryName","value":"Ank_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00520","properties":[{"key":"EntryName","value":"Ion_trans"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01415","properties":[{"key":"EntryName","value":"ANKYRIN"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"14"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"9"}]}],"sequence":{"value":"MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIFCFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETEDDDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP","length":1119,"molWeight":127501,"crc64":"283BF31BC77CF71B","md5":"8E9EC3F002CB07EFA54277E40D13EB05"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":5,"ACTIVITY REGULATION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"DOMAIN":2,"PTM":3,"DISEASE":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Topological domain":8,"Transmembrane":6,"Intramembrane":1,"Repeat":16,"Coiled coil":1,"Binding site":11,"Site":7,"Modified residue":3,"Glycosylation":2,"Disulfide bond":5,"Natural variant":6,"Mutagenesis":19,"Helix":39,"Turn":5,"Beta strand":17},"uniParcId":"UPI000021081A"}}