{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O75477","secondaryAccessions":["B0QZ42","D3DR65","Q53HV0"],"uniProtkbId":"ERLN1_HUMAN","entryAudit":{"firstPublicDate":"2005-06-07","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2019-05-08","entryVersion":185,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16835267"}],"value":"Erlin-1"}},"alternativeNames":[{"fullName":{"value":"Endoplasmic reticulum lipid raft-associated protein 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11118313"}],"value":"Protein KE04"}},{"fullName":{"value":"Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1"},"shortNames":[{"value":"SPFH domain-containing protein 1"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:16947"}],"value":"ERLIN1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:16947"}],"value":"C10orf69"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11118313"}],"value":"KE04"},{"value":"KEO4"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19240031"}],"value":"SPFH1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19240031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24217618"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37683630"}],"value":"Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (PubMed:37683630). Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31810281"}],"value":"(Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19240031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21343306"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21610068"}],"value":"Forms a heteromeric complex with ERLIN2 (PubMed:19240031). In complex with ERLIN2, interacts with RNF170 (PubMed:21610068). Interacts with AMFR and SYVN1 (PubMed:21343306)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O75477","intActId":"EBI-359299"},"interactantTwo":{"uniProtKBAccession":"Q8TD06","geneName":"AGR3","intActId":"EBI-3925742"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75477","intActId":"EBI-359299"},"interactantTwo":{"uniProtKBAccession":"Q9UKV5","geneName":"AMFR","intActId":"EBI-1046367"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75477","intActId":"EBI-359299"},"interactantTwo":{"uniProtKBAccession":"Q12982","geneName":"BNIP2","intActId":"EBI-752094"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75477","intActId":"EBI-359299"},"interactantTwo":{"uniProtKBAccession":"Q7Z4R8","geneName":"C6orf120","intActId":"EBI-11050313"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75477","intActId":"EBI-359299"},"interactantTwo":{"uniProtKBAccession":"O94905","geneName":"ERLIN2","intActId":"EBI-4400770"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75477","intActId":"EBI-359299"},"interactantTwo":{"uniProtKBAccession":"Q7L5A8","geneName":"FA2H","intActId":"EBI-11337888"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75477","intActId":"EBI-359299"},"interactantTwo":{"uniProtKBAccession":"Q8N0V3","geneName":"RBFA","intActId":"EBI-3232108"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75477","intActId":"EBI-359299"},"interactantTwo":{"uniProtKBAccession":"Q96IW7","geneName":"SEC22A","intActId":"EBI-8652744"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75477","intActId":"EBI-359299"},"interactantTwo":{"uniProtKBAccession":"Q15436","geneName":"SEC23A","intActId":"EBI-81088"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75477","intActId":"EBI-359299"},"interactantTwo":{"uniProtKBAccession":"Q86TM6","geneName":"SYVN1","intActId":"EBI-947849"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75477","intActId":"EBI-359299"},"interactantTwo":{"uniProtKBAccession":"Q8N511","geneName":"VMA12","intActId":"EBI-10265825"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O75477","intActId":"EBI-359299"},"interactantTwo":{"uniProtKBAccession":"B2RDE6","intActId":"EBI-10175845"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Associated with lipid raft-like domains of the endoplasmic reticulum membrane"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11118313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16835267"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19240031"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11118313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16835267"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19240031"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11118313"}],"value":"Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37683630"}],"value":"Deubiquitinated by USP25; leading to stabilization"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Spastic paraplegia 62, autosomal recessive","diseaseAccession":"DI-04732","acronym":"SPG62","description":"A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.","diseaseCrossReference":{"database":"MIM","id":"615681"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24482476"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the band 7/mec-2 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAC26658.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH31791.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAD96200.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"Erlin-1","featureId":"PRO_0000002784"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Region","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Glycosylation","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Natural variant","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"in SPG62; dbSNP:rs876661322","featureCrossReferences":[{"database":"dbSNP","id":"rs876661322"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24482476"}],"featureId":"VAR_077847","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"in Ref. 2; BAD96200","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0153","category":"Biological process","name":"Cholesterol metabolism"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0890","category":"Disease","name":"Hereditary spastic paraplegia"},{"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"id":"KW-0446","category":"Ligand","name":"Lipid-binding"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0523","category":"Disease","name":"Neurodegeneration"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0735","category":"Domain","name":"Signal-anchor"},{"id":"KW-0753","category":"Biological process","name":"Steroid metabolism"},{"id":"KW-1207","category":"Biological process","name":"Sterol metabolism"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11118313","citationType":"journal article","authors":["Li N.","Huang X.","Zhao Z.","Chen G.","Zhang W.","Cao X."],"citationCrossReferences":[{"database":"PubMed","id":"11118313"},{"database":"DOI","id":"10.1006/bbrc.2000.3935"}],"title":"Identification and characterization of a novel gene KE04 differentially expressed by activated human dendritic cells.","publicationDate":"2000","journal":"Biochem. Biophys. Res. Commun.","firstPage":"487","lastPage":"493","volume":"279"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Dendritic cell","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-5AVBODINQ93DF","citationType":"submission","authors":["Suzuki Y.","Sugano S.","Totoki Y.","Toyoda A.","Takeda T.","Sakaki Y.","Tanaka A.","Yokoyama S."],"publicationDate":"APR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Adipose tissue","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.R.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.S.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.M.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"19240031","citationType":"journal article","authors":["Pearce M.M.P.","Wormer D.B.","Wilkens S.","Wojcikiewicz R.J.H."],"citationCrossReferences":[{"database":"PubMed","id":"19240031"},{"database":"DOI","id":"10.1074/jbc.m809801200"}],"title":"An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"10433","lastPage":"10445","volume":"284"},"referencePositions":["PROTEIN SEQUENCE","FUNCTION","SUBUNIT","SUBCELLULAR LOCATION","GLYCOSYLATION","INTERACTION WITH ERLIN2"]},{"referenceNumber":7,"citation":{"id":"16835267","citationType":"journal article","authors":["Browman D.T.","Resek M.E.","Zajchowski L.D.","Robbins S.M."],"citationCrossReferences":[{"database":"PubMed","id":"16835267"},{"database":"DOI","id":"10.1242/jcs.03060"}],"title":"Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER.","publicationDate":"2006","journal":"J. Cell Sci.","firstPage":"3149","lastPage":"3160","volume":"119"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":8,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"19159218","citationType":"journal article","authors":["Chen R.","Jiang X.","Sun D.","Han G.","Wang F.","Ye M.","Wang L.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"19159218"},{"database":"DOI","id":"10.1021/pr8008012"}],"title":"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.","publicationDate":"2009","journal":"J. Proteome Res.","firstPage":"651","lastPage":"661","volume":"8"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-108"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-269","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":11,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":12,"citation":{"id":"21343306","citationType":"journal article","authors":["Jo Y.","Sguigna P.V.","DeBose-Boyd R.A."],"citationCrossReferences":[{"database":"PubMed","id":"21343306"},{"database":"DOI","id":"10.1074/jbc.m110.211326"}],"title":"Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.","publicationDate":"2011","journal":"J. Biol. Chem.","firstPage":"15022","lastPage":"15031","volume":"286"},"referencePositions":["INTERACTION WITH AMFR AND SYVN1"]},{"referenceNumber":13,"citation":{"id":"21610068","citationType":"journal article","authors":["Lu J.P.","Wang Y.","Sliter D.A.","Pearce M.M.","Wojcikiewicz R.J."],"citationCrossReferences":[{"database":"PubMed","id":"21610068"},{"database":"DOI","id":"10.1074/jbc.m111.251983"}],"title":"RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation.","publicationDate":"2011","journal":"J. Biol. Chem.","firstPage":"24426","lastPage":"24433","volume":"286"},"referencePositions":["INTERACTION WITH RNF170"]},{"referenceNumber":14,"citation":{"id":"24217618","citationType":"journal article","authors":["Huber M.D.","Vesely P.W.","Datta K.","Gerace L."],"citationCrossReferences":[{"database":"PubMed","id":"24217618"},{"database":"DOI","id":"10.1083/jcb.201305076"}],"title":"Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.","publicationDate":"2013","journal":"J. Cell Biol.","firstPage":"427","lastPage":"436","volume":"203"},"referencePositions":["FUNCTION"]},{"referenceNumber":15,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"24482476","citationType":"journal article","authors":["Novarino G.","Fenstermaker A.G.","Zaki M.S.","Hofree M.","Silhavy J.L.","Heiberg A.D.","Abdellateef M.","Rosti B.","Scott E.","Mansour L.","Masri A.","Kayserili H.","Al-Aama J.Y.","Abdel-Salam G.M.","Karminejad A.","Kara M.","Kara B.","Bozorgmehri B.","Ben-Omran T.","Mojahedi F.","Mahmoud I.G.","Bouslam N.","Bouhouche A.","Benomar A.","Hanein S.","Raymond L.","Forlani S.","Mascaro M.","Selim L.","Shehata N.","Al-Allawi N.","Bindu P.S.","Azam M.","Gunel M.","Caglayan A.","Bilguvar K.","Tolun A.","Issa M.Y.","Schroth J.","Spencer E.G.","Rosti R.O.","Akizu N.","Vaux K.K.","Johansen A.","Koh A.A.","Megahed H.","Durr A.","Brice A.","Stevanin G.","Gabriel S.B.","Ideker T.","Gleeson J.G."],"citationCrossReferences":[{"database":"PubMed","id":"24482476"},{"database":"DOI","id":"10.1126/science.1247363"}],"title":"Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.","publicationDate":"2014","journal":"Science","firstPage":"506","lastPage":"511","volume":"343"},"referencePositions":["INVOLVEMENT IN SPG62","VARIANT SPG62 VAL-50"]},{"referenceNumber":17,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":18,"citation":{"id":"31810281","citationType":"journal article","authors":["Whitten-Bauer C.","Chung J.","Gomez-Moreno A.","Gomollon-Zueco P.","Huber M.D.","Gerace L.","Garaigorta U."],"citationCrossReferences":[{"database":"PubMed","id":"31810281"},{"database":"DOI","id":"10.3390/cells8121555"}],"title":"The Host Factor Erlin-1 is Required for Efficient Hepatitis C Virus Infection.","publicationDate":"2019","journal":"Cells","firstPage":"0","lastPage":"0","volume":"8"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)"]},{"referenceNumber":19,"citation":{"id":"37683630","citationType":"journal article","authors":["Teo Q.W.","Wong H.H.","Heunis T.","Stancheva V.","Hachim A.","Lv H.","Siu L.","Ho J.","Lan Y.","Mok C.K.P.","Ulferts R.","Sanyal S."],"citationCrossReferences":[{"database":"PubMed","id":"37683630"},{"database":"DOI","id":"10.1016/j.devcel.2023.08.013"}],"title":"Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection.","publicationDate":"2023","journal":"Dev. Cell","firstPage":"2495","lastPage":"2509","volume":"58"},"referencePositions":["FUNCTION","DEUBIQUITINATION BY USP25"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF064093","properties":[{"key":"ProteinId","value":"AAC26658.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK222480","properties":[{"key":"ProteinId","value":"BAD96200.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL138921","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471066","properties":[{"key":"ProteinId","value":"EAW49846.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471066","properties":[{"key":"ProteinId","value":"EAW49847.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC031791","properties":[{"key":"ProteinId","value":"AAH31791.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS7487.2","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001094096.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001100626.2"}]},{"database":"RefSeq","id":"NP_001334786.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001347857.2"}]},{"database":"RefSeq","id":"NP_001334788.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001347859.2"}]},{"database":"RefSeq","id":"NP_001334789.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001347860.2"}]},{"database":"RefSeq","id":"NP_001334790.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001347861.2"}]},{"database":"RefSeq","id":"NP_006450.2","properties":[{"key":"NucleotideSequenceId","value":"NM_006459.4"}]},{"database":"PDB","id":"9O9U","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M=3-348"}]},{"database":"PDBsum","id":"9O9U","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70263","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"115859","properties":[{"key":"Interactions","value":"216"}]},{"database":"ComplexPortal","id":"CPX-7121","properties":[{"key":"EntryName","value":"ERLIN1-ERLIN2 complex"}]},{"database":"CORUM","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O75477","properties":[{"key":"Number of interactors","value":"1234"}]},{"database":"IntAct","id":"O75477","properties":[{"key":"Interactions","value":"135"}]},{"database":"MINT","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000410964","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL6067009","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.P.1.1.1","properties":[{"key":"FamilyName","value":"the polyoma virus sv40 er penetration channel (vpec) family"}]},{"database":"TCDB","id":"8.A.195.1.1","properties":[{"key":"FamilyName","value":"the erlin1/2 complex (erlin) family"}]},{"database":"GlyConnect","id":"O75477","properties":[{"key":"glycosylation","value":"10 N-Linked glycans (1 site)"}]},{"database":"GlyCosmos","id":"O75477","properties":[{"key":"glycosylation","value":"1 site, 10 glycans"}]},{"database":"GlyGen","id":"O75477","properties":[{"key":"glycosylation","value":"2 sites, 10 N-linked glycans (1 site), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ERLIN1","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000410964","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"PRIDE","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"50039","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"2279","properties":[{"key":"antibodies","value":"210 antibodies from 30 providers"}]},{"database":"DNASU","id":"10613","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000407654.7","properties":[{"key":"ProteinId","value":"ENSP00000384900.3"},{"key":"GeneId","value":"ENSG00000107566.15"}]},{"database":"Ensembl","id":"ENST00000421367.7","properties":[{"key":"ProteinId","value":"ENSP00000410964.2"},{"key":"GeneId","value":"ENSG00000107566.15"}]},{"database":"GeneID","id":"10613","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:10613","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000421367.7","properties":[{"key":"ProteinId","value":"ENSP00000410964.2"},{"key":"RefSeqNucleotideId","value":"NM_006459.4"},{"key":"RefSeqProteinId","value":"NP_006450.2"}]},{"database":"UCSC","id":"uc001kqn.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:16947","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162385299","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"10613","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"10613","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ERLIN1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:16947","properties":[{"key":"GeneName","value":"ERLIN1"}]},{"database":"HPA","id":"ENSG00000107566","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (liver)"}]},{"database":"MalaCards","id":"ERLIN1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"611604","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"615681","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000107566","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"401785","properties":[{"key":"Disease","value":"Autosomal recessive spastic paraplegia type 62"}]},{"database":"Orphanet","id":"300605","properties":[{"key":"Disease","value":"Juvenile amyotrophic lateral sclerosis"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000107566","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2962","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000014666","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HIMIPIL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"77368at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"O75477","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-382556","properties":[{"key":"PathwayName","value":"ABC-family proteins mediated transport"}]},{"database":"Reactome","id":"R-HSA-5678895","properties":[{"key":"PathwayName","value":"Defective CFTR causes cystic fibrosis"}]},{"database":"Reactome","id":"R-HSA-9931269","properties":[{"key":"PathwayName","value":"AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)"}]},{"database":"SignaLink","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"O75477","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000107566","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"10613","properties":[{"key":"hits","value":"21 hits in 1154 CRISPR screens"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"ERLIN1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"ERLIN1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"10613","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"O75477","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:O75477","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"RNAct","id":"O75477","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000107566","properties":[{"key":"ExpressionPatterns","value":"Expressed in secondary oocyte and 214 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"O75477","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16835267"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19240031"}]},{"database":"GO","id":"GO:0045121","properties":[{"key":"GoTerm","value":"C:membrane raft"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"34572057"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18468998"}]},{"database":"GO","id":"GO:0015485","properties":[{"key":"GoTerm","value":"F:cholesterol binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24217618"}]},{"database":"GO","id":"GO:0031625","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008203","properties":[{"key":"GoTerm","value":"P:cholesterol metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-KW"}]},{"database":"GO","id":"GO:0036503","properties":[{"key":"GoTerm","value":"P:ERAD pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19240031"}]},{"database":"GO","id":"GO:0045541","properties":[{"key":"GoTerm","value":"P:negative regulation of cholesterol biosynthetic process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24217618"}]},{"database":"GO","id":"GO:0045717","properties":[{"key":"GoTerm","value":"P:negative regulation of fatty acid biosynthetic process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24217618"}]},{"database":"GO","id":"GO:0045540","properties":[{"key":"GoTerm","value":"P:regulation of cholesterol biosynthetic process"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24217618"}]},{"database":"GO","id":"GO:0032933","properties":[{"key":"GoTerm","value":"P:SREBP signaling pathway"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24217618"}]},{"database":"CDD","id":"cd03406","properties":[{"key":"EntryName","value":"SPFH_like_u3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.479.30:FF:000009","properties":[{"key":"EntryName","value":"Erlin-2 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.479.30","properties":[{"key":"EntryName","value":"Band 7 domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001107","properties":[{"key":"EntryName","value":"Band_7"}]},{"database":"InterPro","id":"IPR036013","properties":[{"key":"EntryName","value":"Band_7/SPFH_dom_sf"}]},{"database":"InterPro","id":"IPR033294","properties":[{"key":"EntryName","value":"Erlin1/2"}]},{"database":"PANTHER","id":"PTHR15351","properties":[{"key":"EntryName","value":"ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15351:SF2","properties":[{"key":"EntryName","value":"ERLIN-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01145","properties":[{"key":"EntryName","value":"Band_7"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00244","properties":[{"key":"EntryName","value":"PHB"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF117892","properties":[{"key":"EntryName","value":"Band 7/SPFH domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNMTQARVLVAAVVGLVAVLLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNLMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKKAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDIRTGRESSLPSKEALEPSGENVIQNKESTG","length":348,"molWeight":39171,"crc64":"C643FEADBE9095DE","md5":"69B6EB52050AA11440BE2E0FEB5D12F7"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"INTERACTION":12,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"PTM":1,"DISEASE":1,"SIMILARITY":1,"SEQUENCE CAUTION":3},"countByFeatureType":{"Chain":1,"Topological domain":2,"Transmembrane":1,"Region":1,"Compositional bias":1,"Modified residue":1,"Glycosylation":1,"Natural variant":1,"Sequence conflict":1},"uniParcId":"UPI0000155AF8"}}