{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B8XCM9","uniProtkbId":"B8XCM9_9MONO","entryAudit":{"firstPublicDate":"2009-03-03","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2009-03-03","entryVersion":60,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Bundibugyo virus","taxonId":565995,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACI28622.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000143891"}],"lineage":["Viruses","Riboviria","Orthornavirae","Negarnaviricota","Haploviricotina","Monjiviricetes","Mononegavirales","Filoviridae","Orthoebolavirus","Orthoebolavirus bundibugyoense"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017011"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR018327"}],"value":"Matrix protein VP40"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR018327"}],"value":"Membrane-associated protein VP40"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACI28622.1"}],"value":"VP40"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045627"}],"value":"Plays an essential role virus particle assembly and budding. Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101. The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding. May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR018327"}],"value":"Plays an essential role virus particle assembly and budding. Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00046555"}],"value":"Homodimer. Homohexamer. Homooctamer. Exists as a dimer until it reorganizes at the plasma membrane into a hexameric form using phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). Hexamers are critical for budding. Octamers function in genome replication and RNA binding. Interacts with host TSG101. As a homohexamer, interacts with the WW domain 3 of host NEDD4. Interacts with the nucleoprotein/NP. Interacts (via YPx(n)L/I motif) with host PDCD6IP/ALIX; this interaction supports efficient egress of viral particles. Interacts with VP35. Interacts with host ITCH; this interaction is required for efficient egress. Interacts (via PPXY motif) with host SMURF2 (via WW domains); the interaction positively regulates virus budding"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR018327"}],"value":"In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and probably also in multivesicular bodies. These VP40-enriched membrane clusters are then redistributed to the plasma membrane where budding takes place"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004501"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR018327"}],"value":"Host cell membrane","id":"SL-0375"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004501"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR018327"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004501"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR018327"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004261"}],"value":"Host late endosome 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family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022511"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR018327"}],"id":"KW-1032","category":"Cellular component","name":"Host cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023046"}],"id":"KW-1039","category":"Cellular component","name":"Host endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022870"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR018327"}],"id":"KW-1043","category":"Cellular component","name":"Host membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022581"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR018327"}],"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022632"}],"id":"KW-1090","category":"Biological 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