{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0U2MN53","uniProtkbId":"A0A0U2MN53_MERS","entryAudit":{"firstPublicDate":"2016-03-16","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2016-03-16","entryVersion":27,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Middle East respiratory syndrome-related coronavirus","commonName":"MERS-CoV","taxonId":1335626,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALJ54495.1"}],"lineage":["Viruses","Riboviria","Orthornavirae","Pisuviricota","Pisoniviricetes","Nidovirales","Cornidovirineae","Coronaviridae","Orthocoronavirinae","Betacoronavirus","Merbecovirus","Betacoronavirus cameli"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Spike glycoprotein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"S glycoprotein"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"E2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Peplomer protein"}}],"contains":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Spike protein S1"}}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Spike protein S2"}}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Spike protein S2'"}}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"S"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Virion membrane","id":"SL-0275"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Host endoplasmic reticulum-Golgi intermediate compartment membrane","id":"SL-0392"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Host cell membrane","id":"SL-0375"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Fusion peptide 1 (FP1) and fusion peptide 2 (FP2) function cooperatively and have a membrane-ordering effect on lipid headgroups and shallow hydrophobic regions of target bilayers. They are considered as two domains of an extended, bipartite FP. The membrane-ordering activity is calcium-dependent and also dependent on correct folding, which is maintained by an internal disulfide bond in FP2"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Specific enzymatic cleavages in vivo yield mature proteins. The precursor is processed into S1 and S2 by host cell furin or another cellular protease to yield the mature S1 and S2 proteins. Additionally, a second cleavage leads to the release of a fusion peptide after viral attachment to host cell receptor"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"The cytoplasmic Cys-rich domain is palmitoylated. Spike glycoprotein is digested within host endosomes"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Belongs to the betacoronaviruses spike protein family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Chain","location":{"start":{"value":748,"modifier":"EXACT"},"end":{"value":1353,"modifier":"EXACT"}},"description":"Spike protein S2","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"featureId":"PRO_5023556274"},{"type":"Chain","location":{"start":{"value":888,"modifier":"EXACT"},"end":{"value":1353,"modifier":"EXACT"}},"description":"Spike protein S2'","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"featureId":"PRO_5023556275"},{"type":"Transmembrane","location":{"start":{"value":1297,"modifier":"EXACT"},"end":{"value":1320,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Topological domain","location":{"start":{"value":1318,"modifier":"EXACT"},"end":{"value":1353,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}]},{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"BetaCoV S1-NTD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51922"}]},{"type":"Domain","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":587,"modifier":"EXACT"}},"description":"BetaCoV S1-CTD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51921"}]},{"type":"Domain","location":{"start":{"value":970,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51923"}]},{"type":"Domain","location":{"start":{"value":1226,"modifier":"EXACT"},"end":{"value":1307,"modifier":"EXACT"}},"description":"Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51924"}]},{"type":"Region","location":{"start":{"value":888,"modifier":"EXACT"},"end":{"value":909,"modifier":"EXACT"}},"description":"Fusion peptide 1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}]},{"type":"Region","location":{"start":{"value":994,"modifier":"EXACT"},"end":{"value":1044,"modifier":"EXACT"}},"description":"Heptad repeat 1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}]},{"type":"Region","location":{"start":{"value":1246,"modifier":"EXACT"},"end":{"value":1285,"modifier":"EXACT"}},"description":"Heptad repeat 2","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}]},{"type":"Coiled coil","location":{"start":{"value":1023,"modifier":"EXACT"},"end":{"value":1067,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}]},{"type":"Coiled coil","location":{"start":{"value":1258,"modifier":"EXACT"},"end":{"value":1286,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}]},{"type":"Motif","location":{"start":{"value":1349,"modifier":"EXACT"},"end":{"value":1353,"modifier":"EXACT"}},"description":"KxHxx","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}]},{"type":"Site","location":{"start":{"value":887,"modifier":"EXACT"},"end":{"value":888,"modifier":"EXACT"}},"description":"Cleavage","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}]},{"type":"Disulfide bond","location":{"start":{"value":425,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022510"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-1170","category":"Biological process","name":"Fusion of virus membrane with host endosomal membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022506"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-1168","category":"Biological process","name":"Fusion of virus membrane with host membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022511"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-1032","category":"Cellular component","name":"Host cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022870"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-1043","category":"Cellular component","name":"Host membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022581"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023139"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022804"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-1161","category":"Biological process","name":"Viral attachment to host cell"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022879"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-0261","category":"Cellular component","name":"Viral envelope protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022595"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-1162","category":"Biological process","name":"Viral penetration into host cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022844"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-0946","category":"Cellular component","name":"Virion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023026"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-0843","category":"Biological process","name":"Virulence"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023296"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_04099"}],"id":"KW-1160","category":"Biological process","name":"Virus entry into host cell"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-C4FRJ6OI180D1","citationType":"submission","authors":["Lu X.","Assiri A.M.","Erdman D.D."],"title":"Emergence and circulation of a novel recombinant lineage of MERS-CoV in Saudi Arabia.","publicationDate":"SEP-2015","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALJ54495.1"}],"value":"Hu/Makkah-KSA-907/2015","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALJ54495.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KT806015","properties":[{"key":"ProteinId","value":"ALJ54495.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"GO","id":"GO:0044173","properties":[{"key":"GoTerm","value":"C:host cell endoplasmic reticulum-Golgi intermediate compartment membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0020002","properties":[{"key":"GoTerm","value":"C:host cell plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0019031","properties":[{"key":"GoTerm","value":"C:viral envelope"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0055036","properties":[{"key":"GoTerm","value":"C:virion membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0075509","properties":[{"key":"GoTerm","value":"P:endocytosis involved in viral entry into host cell"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0039654","properties":[{"key":"GoTerm","value":"P:fusion of virus membrane with host endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0019064","properties":[{"key":"GoTerm","value":"P:fusion of virus membrane with host plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0046813","properties":[{"key":"GoTerm","value":"P:receptor-mediated virion attachment to host cell"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd21486","properties":[{"key":"EntryName","value":"human_MERS-CoV_Spike_S1_RBD"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd21626","properties":[{"key":"EntryName","value":"MERS-CoV-like_Spike_S1_NTD"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd22379","properties":[{"key":"EntryName","value":"MERS-CoV-like_Spike_SD1-2_S1-S2_S2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"2.20.210.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1840","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.960","properties":[{"key":"EntryName","value":"Spike glycoprotein, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_04099","properties":[{"key":"EntryName","value":"BETA_CORONA_SPIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR032500","properties":[{"key":"EntryName","value":"bCoV_S1_N"}]},{"database":"InterPro","id":"IPR042578","properties":[{"key":"EntryName","value":"BETA_CORONA_SPIKE"}]},{"database":"InterPro","id":"IPR043473","properties":[{"key":"EntryName","value":"S2_sf_CoV"}]},{"database":"InterPro","id":"IPR043002","properties":[{"key":"EntryName","value":"Spike_N_sf"}]},{"database":"InterPro","id":"IPR044337","properties":[{"key":"EntryName","value":"Spike_S1_N_MERS-CoV-like"}]},{"database":"InterPro","id":"IPR018548","properties":[{"key":"EntryName","value":"Spike_S1_RBD_bCoV"}]},{"database":"InterPro","id":"IPR044376","properties":[{"key":"EntryName","value":"Spike_S1_RBD_MERS-CoV"}]},{"database":"InterPro","id":"IPR036326","properties":[{"key":"EntryName","value":"Spike_S1_RBD_sf_bCoV"}]},{"database":"InterPro","id":"IPR002552","properties":[{"key":"EntryName","value":"Spike_S2_CoV"}]},{"database":"InterPro","id":"IPR043614","properties":[{"key":"EntryName","value":"Spike_S2_CoV_C"}]},{"database":"InterPro","id":"IPR044873","properties":[{"key":"EntryName","value":"Spike_S2_CoV_HR1"}]},{"database":"InterPro","id":"IPR044874","properties":[{"key":"EntryName","value":"Spike_S2_CoV_HR2"}]},{"database":"Pfam","id":"PF16451","properties":[{"key":"EntryName","value":"bCoV_S1_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09408","properties":[{"key":"EntryName","value":"bCoV_S1_RBD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01601","properties":[{"key":"EntryName","value":"CoV_S2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19214","properties":[{"key":"EntryName","value":"CoV_S2_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF111474","properties":[{"key":"EntryName","value":"Coronavirus S2 glycoprotein"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF143587","properties":[{"key":"EntryName","value":"SARS receptor-binding domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51921","properties":[{"key":"EntryName","value":"BCOV_S1_CTD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51922","properties":[{"key":"EntryName","value":"BCOV_S1_NTD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51923","properties":[{"key":"EntryName","value":"COV_S2_HR1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51924","properties":[{"key":"EntryName","value":"COV_S2_HR2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIHSVFLLMFLLTPTESYVDVGPDSVKSACIEVDIQQTFFDKTWPRPIDVSKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYVYSAGHATGTTPQKLFVANYSQDVKQFANGFVVRIGAAANSTGTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYCILEPRSGNHCPAGNSYTSFATYHTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYTYNITEDEILEWFGITQTAQGVHLFSSRYVDLYGGNMFQFATLPVYDTIKYYSIIPHSIRSIQSDRKAWAAFYVYKLQPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQAEGVECDFSPLLSGTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCSRLLSDDRTEVPQLVNANQYSPCVSIVPSTVWEDGDYYRKQLSPLEGGGWLVVSGSTVAMTEQLQMGFGITVQYGTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVFQNCTAVGVRQQRFVYDAYQNLVGYYSDDGNYYCLRACVSVPVSVIYDKETKTHATLFGSVACEHISSTMSQYSRSTRSMLKRRDSTYGPLQTPVGCVLGLVNSSLFVEDCKLPLGQSLCALPDTPSTLTPRSVRSVPGEMRLASIAFNHPIQVDQLNSSYFKLSIPTNFSFGVTQEYIQTTIQKVTVDCKQYVCNGFQKCEQLLREYGQFCSKINQALHGANLRQDDSVRNLFASVKSSQSSPIIPGFGGDFNLTLLEPVSISTGSRSARSAIEDLLFDKVTIADPGYMQGYDDCMQQGPASARDLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGVGWTAGLSSFAAIPFAQSIFYRLNGVGITQQVLSENQKLIANKFNQALGAMQTGFTTTNEAFRKVQDAVNNNAQALSKLASELSNTFGAISASIGDIIQRLDVLEQDAQIDRLINGRLTTLNAFVAQQLVRSESAALSAQLAKDKVNECVKAQSKRSGFCGQGIHIVSFVVNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAANPTNCIAPVNGYFIKTNNTRIVDEWSYTGSSFYAPEPITSLNTKYVAPQVTYQNISTNLPPPLLGNSTGIDFQDELDEFFKNVSTSIPNFGSLTQINTTLLDLTYEMLSLQQVVKALNESYIDLKELGNYTYYNKWPWYIWLGFIAGLVALALCVFFILCCTGCGTNCMGKLKCNRCCDRYEEYDLEPHKVHVH","length":1353,"molWeight":149436,"crc64":"41462942C57AB93B","md5":"E674BEEF5D7A1C4C256602BC92109B56"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"PTM":2,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Chain":2,"Transmembrane":1,"Topological domain":1,"Domain":4,"Region":3,"Coiled coil":2,"Motif":1,"Site":1,"Disulfide bond":1},"uniParcId":"UPI00073DD82D"}}